Status:
COMPLETED
Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery
Lead Sponsor:
Population Health Research Institute
Conditions:
Bleeding
Surgical Blood Loss
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
The aim is to conduct a double-blinded single-centre randomized controlled clinical trial of application of topical dose of tranexamic acid (TA) versus the usual intravenous TA in patients undergoing ...
Detailed Description
Postoperative bleeding related to open cardiac surgery increases the rates of complications and mortality. It results from the blood thinners that are needed for use. Intravenous tranexamic acid (TA) ...
Eligibility Criteria
Inclusion
- Male or female \>= 18 years old
- Undergoing cardiac surgical procedure with the use of cardiopulmonary bypass and median sternotomy
- Provide written informed consent
Exclusion
- Poor (English) language comprehension
- Minimally invasive valve surgery
- Off-pump procedures
- Emergency operations
- Known history of increased bleeding disorder
- Thromboembolic disease
- Allergy to tranexamic acid
- Severe renal impairment (eGFR \<30 mL/min/1.73m2 )
Key Trial Info
Start Date :
December 21 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 4 2018
Estimated Enrollment :
97 Patients enrolled
Trial Details
Trial ID
NCT03376061
Start Date
December 21 2017
End Date
September 4 2018
Last Update
February 11 2021
Active Locations (1)
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1
Hamilton General Hospital
Hamilton, Ontario, Canada, L8L 2X2