Status:
COMPLETED
Trial of Probiotics for Constipation in Parkinson's Disease
Lead Sponsor:
University of Malaya
Conditions:
Parkinson Disease
Eligibility:
All Genders
40-85 years
Phase:
NA
Brief Summary
This is a double blinded randomised placebo controlled trial to evaluate the efficacy of probiotics in the treatment of constipation in Parkinson's disease.
Eligibility Criteria
Inclusion
- Age 50 to 80 years old
- Provision of written informed consent
- Diagnosis of PD made by a Neurologist using UK Brain Bank Criteria
- Fulfils criteria for functional constipation according to the Rome IV Criteria during in the preceding 6 months with frequency of bowel movements less than 3 times per week
Exclusion
- Ingestion of probiotics in the preceding 4 weeks
- Use of antibiotics in the preceding 4 weeks
- History of gastrointestinal disorders or surgery
- Known or suspected allergy to probiotics
- Comorbidities that prevent reliable completion of study assessments
- Prior functional neurosurgery for PD or treatment with apomorphine infusion
- Recent initiation of dopaminergic medications in the preceding 3 months
Key Trial Info
Start Date :
December 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 31 2019
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT03377322
Start Date
December 1 2017
End Date
January 31 2019
Last Update
October 30 2019
Active Locations (1)
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1
University of Malaya
Kuala Lumpur, Kuala Lumpur, Malaysia, 59100