Status:
COMPLETED
Narcolepsy Protect Against Alzheimer's Disease?
Lead Sponsor:
University Hospital, Montpellier
Conditions:
Narcolepsy
Amyloid Pathology
Eligibility:
All Genders
65-85 years
Phase:
NA
Brief Summary
Links between orexin and amyloid processes have been underlined recently. During the Alzheimer's process an upregulation of the orexin mechanism has been observed. The pathophysiological mechanism of ...
Detailed Description
The lack of innovative treatments in Alzheimer' disease (AD) is due to the non-understanding of the pathological process. The investigators need to include the latest concept of the sleep-wake/circadi...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Narcolepsy group:
- Patients with narcolepsy type 1 older than 65 y.o. with orexin deficiency as required by international diagnosis criteria (ICSD3) with a follow-up in the national reference center for narcolepsy;
- Treated or not with psychostimulant drugs in relation to disease symptoms;
- Patients with CSF samples available or with scheduled lumbar puncture for diagnosis purpose;
- No contra-indications of the PET-scan18F-AV-45
- With a free and informed consent to participate to the study.
- Control group:
- Subjects already included in the MEMENTO-AMYging and/or MAPT-AV45 ancillary studies in the memory center with normal cognitive tests after neuropsychological assessments especially in the episodic memory tests and the brain amyloid PET-scan18F-AV-45 data with SuVr measurements.
- Exclusion criteria:
- Controls subjects or patients without free and informed consent to participate to the study
- No PET-scan18F-AV-45 data available
- No CSF samples
- Pathologies being life-threatening in a short term
- Patients deprived of freedom by court or administrative order
- Patients living in institution
- Major protected by the Law.
Exclusion
Key Trial Info
Start Date :
April 7 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2017
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT03378453
Start Date
April 7 2016
End Date
November 1 2017
Last Update
December 19 2017
Active Locations (1)
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1
Montpellier University Hospital, Gui de Chauliac
Montpellier, France, 34295