Status:
COMPLETED
HEPAR Primary: Holmium-166-radioembolization in Hepatocellular Carcinoma Patients
Lead Sponsor:
UMC Utrecht
Collaborating Sponsors:
Dutch Cancer Society
Erasmus Medical Center
Conditions:
Hepatocellular Carcinoma
Hepatocellular Carcinoma Non-resectable
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
Patients with hepatocellular carcinoma often die from intrahepatic disease since current treatment options are generally limited. Local treatment using holmium radioembolization could offer an effecti...
Detailed Description
Primary objective: • To establish the safety and toxicity profile of holmium radioembolization in patients with hepatocellular carcinoma. Secondary objectives: * To evaluate efficacy of holmium rad...
Eligibility Criteria
Inclusion
- Patients must have given written informed consent.
- Female or male aged 18 years and over.
- Diagnosis of HCC established according to the Netherlands HCC guideline criteria (in line with American AASLD criteria): nodule \>1 cm in a patient at risk for HCC, with combination of arterial hypervascularity and venous or delayed phase wash-out on multiphase CT-scan or MRI-scan.2, 4 LR-5 and LR- 4 based on Liver Imaging Reporting and Data System can be included based on discretion of the principal investigator.I
- No curative treatment options (resection, transplant, or in case of solitary tumor \<5 cm, RFA).
- Life expectancy of at least 6 months.
- ECOG Performance status 0-1 (Table 2).
- Liver-dominant disease (maximum 5 lung nodules all ≤1.0 cm and mesenteric or portal lymph nodes all ≤2.0 cm are accepted).
- Child-Pugh class A5-6 or B7.
- At least one measurable liver lesion according to the modified RECIST criteria.21
- Negative pregnancy test for women of childbearing potential. Female patients of child-bearing potential should use an highly effective acceptable method of contraception (oral contraceptives, barrier methods, approved contraceptive implant, long-term injectable contraception, intrauterine device or tubal ligation) or should be more than 1 year postmenopausal or surgically sterile during their participation in this study (from the time they sign the consent form), to prevent pregnancy.
Exclusion
- Evidence of significant extrahepatic disease (MRI-scan liver and multiphase abdominal CT as well as a thoracic CT are routinely performed at screening).
- Radiation therapy within the last 4 weeks before the start of study therapy.
- Previous or current treatment with RE. Previous treatment with TACE, surgery, RFA, and previous or current treatment with sorafenib are allowed.
- Major surgery within 4 weeks or incompletely healed surgical incision before starting study therapy.
- Serum bilirubin \>34.2 micromole/L (2 mg/dL).
- Glomerular filtration rate \<35 ml/min, determined according to the Modification of Diet in Renal Disease formula.
- Non-correctable INR \>1.5 in case of femoral approach (as opposed to radial).
- Leukocytes \<2 109/l and/or platelet count \<50 109/l.
- Significant cardiac event (e.g. myocardial infarction, superior vena cava (SVC) syndrome, New York Heart Association (NYHA) classification of heart disease ≥2 within 3 months before entry, or presence of cardiac disease that in the opinion of the Investigator increases the risk of ventricular arrhythmia.
- Pregnancy or breastfeeding.
- Patients suffering from psychic disorders that make a comprehensive judgment impossible, such as psychosis, hallucinations and/or depression.
- Patients who are declared incapacitated.
- Previous enrollment in the present study.
- Male patients who are not surgically sterile or do not use an acceptable method of contraception during their participation in this study (from the time they sign the consent form) to prevent pregnancy in a partner.
- Evidence of untreated, clinically significant grade 3 portal hypertension (i.e. large varices at oesophago-gastro-duodenoscopy). In these cases, therapy with non-selective beta blocker (propranolol) or rubber band ligation should be instituted according to accepted guidelines. In case of small varices, prophylactic propranolol is advised.
- Portal vein thrombosis (tumor and/or bland) of the main branch (diagnosed on contrast enhanced transaxial images). Involvement of the right or left portal vein branches and more distal is accepted.
- Untreated active hepatitis. In case of detectable viral HBV load, treatment with a nucleos(t)ide analog such as entecavir or tenofovir should be instituted.
- Transjugular intrahepatic portosystemic shunt (TIPS).
- Body weight over 150 kg (because of maximum table load).
- Severe allergy for intravenous contrast used (Visipaque®)(because of CT evaluation, pre-treatment angiography and treatment angiography).
- Lung shunt \>30 Gy, as calculated using scout dose SPECT/CT.
- Uncorrectable extrahepatic deposition of scout dose activity. Activity in the falciform ligament, portal lymph nodes and gallbladder is accepted.
Key Trial Info
Start Date :
August 21 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2021
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03379844
Start Date
August 21 2017
End Date
August 1 2021
Last Update
November 8 2022
Active Locations (2)
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1
Erasmus Medical Center
Rotterdam, Netherlands, 3015CN
2
University Medical Center Utrecht
Utrecht, Netherlands, 3584 CX