Status:
WITHDRAWN
Clinical Trial to eLiminate HCV-infection in Treatment-naïve, Renally Impaired EgyptiAn Patients on Renal Dialysis, With Chronic Hepatitis C Genotype 4
Lead Sponsor:
University of Maryland, Baltimore
Collaborating Sponsors:
Merck Sharp & Dohme LLC
Cairo University
Conditions:
Hepatitis C Virus Infection, Response to Therapy of
Eligibility:
All Genders
21-70 years
Phase:
PHASE4
Brief Summary
Primary Efficacy Objective -To assess whether a 12-week treatment course with oral 50 mg elbasvir plus 100 mg grazoprevir given in a single daily dose to treatment-naïve patients with end-stage renal...
Eligibility Criteria
Inclusion
- Signed and dated informed consent obtained before undergoing any trial-related procedures
- Male and female patients; age between 21 and 70 years inclusive
- Chronic hepatitis C infection with genotype 4 confirmed by genotypic testing at screening or within 6 months of screening period
- Treatment naïve - absence of prior failed treatment for HCV with Interferon plus ribavirin therapy or directly acting antivirals (treatment experienced)
- Detectable HCV viral load (quantitative)
- Liver cirrhosis subjects may be included but will be limited to those with compensated liver disease
- Chronic kidney disease with end-stage liver disease (defined as glomerular filtration rate \[eGFR\] \<=15 mL/min/1.73m2) on hemodialysis for at least 3 months, including individuals awaiting kidney transplant and those with failed kidney transplants but no longer on immunosuppressant therapy)
- Screening laboratory values within the defined protocol thresholds
- Women of child-bearing potential, must agree to abstinence or use of effective contraceptive methods (e.g. oral or injectable contraceptives, intra-uterine device (IUD), transdermal contraceptive patch) at least 2 weeks prior Day 1 through 14 days after the last dose of the study drug.
- Ability to communicate, participate, and comply with the requirements of the entire study
Exclusion
- Patients didn't sign informed consent or under age of legal consent
- Pregnant or breastfeeding woman
- Has HCV genotypes other than G4
- On peritoneal dialysis for management of kidney disease
- Co-Infection with HIV and/or HBV (with positive HBsAg)
- Evidence of hepatocellular carcinoma (HCC)
- Evidence of hepatic decompensation as evidenced by presence or history of ascites, esophaegal or gastric bleeding, hepatic encelopathy or other signs of or symptoms of advanced liver disease, or cirrhotic subjects with Child-Pugh B or C, or who have a Purgh-Turcotte (CPT) score \>6
- Active or suspected non-hepatic malignancy or history of any malignancy except for cured basal cell or squamous cell skin cancer or in situ cervical cancer
- Organ transplant (including hematopoietic stem cell transplant) other than kidney, cornea, and hair
- Conditions requiring, or likely to require, chronic systemic administration of corticosteroids during the course of the trial
- Uncontrolled or poorly controlled hypertension
- Pregnant, breast-feeding, expecting to conceive or donate eggs, or donate sperm from Day 1 through 14 days after the last study dose.
- Significant cardiovascular disorder (e.g. myocardial infarction or unstable angina) or interventional cardiovascular procedure within 3 months prior to signing informed consent
- Recent (within 3 months prior to signing informed consent) episode or recurrence of stroke, transient ischemic attack (TIA) or neurological disorder, including but not limited to seizures
- ALT or AST \> 10-fold the upper limit of normal
- Evidence of liver disease due to causes other than chronic HCV infection
- Evidence of poorly controlled diabetes (defined as HbA1c \> 8%)
- History of alcohol or drug abuse within the last 12 months
- Serum albumin level \< 3.0 g/dL
- INR \> 1.3 N
- Total Bilirubin levels \> 2.0 mg/dL unless explained by Gilbert's disease
- Platelets Count \<75,000/µL
- White blood cell count \< 1500 µL (mm3)
- Clinically significant TSH and T4 level poorly controlled thyroid function
- Patients with any abnormality on physical examination, vital signs (sitting systolic blood pressure greater than 150 mmHg, sitting diastolic blood pressure greater than 90 mmHg and pulse greater than 90 bpm) and ECG, unless these abnormalities are judged to be not clinically significant by the Investigator
- Body Mass Index \< 18.5 or \> 35 kg/m2
- Use of other investigational drugs/treatments within the previous 3 months
- Known hypersensitivity to any of the test materials or related compounds.
- Active autoimmune disease.
- History of moderate, severe or uncontrolled psychiatric disease, especially severe depression and prior suicidal attempt.
- Unable to comply with research study visits.
- Poor venous access not allowing screening laboratory collection.
- Any other condition that, in the opinion of the Investigator, may be a contraindication to study participation or jeopardize the study conduct according to the protocol.
Key Trial Info
Start Date :
December 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2020
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT03381859
Start Date
December 1 2019
End Date
June 1 2020
Last Update
April 20 2020
Active Locations (1)
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1
Kasr Alainy Hospital
Cairo, Almanial, Egypt