Status:
COMPLETED
Exploration of the Modulation of Skin Microbiota and Odor Components by Introduction of Stress in Healthy Male Subjects
Lead Sponsor:
NIZO Food Research
Collaborating Sponsors:
Procter and Gamble
Conditions:
Emotional Stress
Eligibility:
MALE
18-34 years
Phase:
NA
Brief Summary
In the MOIST study it will be assessed whether the adapted Sternberg short-term working memory task (STMST) is an effective method to induce malodor formation by emotional stress, as assessed by exper...
Detailed Description
Stress is a primary physiological response to physical and/or social threats resulting from a complex interplay of neurophysiological and psychological factors. Cognitive interpretations of social-eva...
Eligibility Criteria
Inclusion
- Male;
- Age 18-34 yrs;
- BMI between 18,5-25 kg/m2;
- Healthy as assessed by the NIZO lifestyle and health questionnaire;
- Non-smoking;
- Signed informed consent;
- Malodor score ≥ 4≤ 8 as assessed by malodor judges
- Access to internet;
- Voluntary participation;
- Willing to accept disclosure of the financial benefit of participation in the study to the authorities concerned;
- Willing to accept use of all encoded data, including publication, and the confidential use and storage of all data for the study for at least 15 years;
- Willing to accept information-transfer concerning participation in the study, or information regarding health, like laboratory results, findings at anamnesis or physical examination and eventual adverse events to and from his general practitioner;
- Willing to comply with study procedures.
Exclusion
- Alcohol consumption \> 15 units/week and \> 3/day;
- Drug abuse;
- Former participation in a cognitively challenging computer task or mental performance test;
- Heavy exercise or sports training \> 10 hours/week;
- Hyperhidrosis , Hypohidrosis or Anhidrosis;
- Known allergy to cosmetics;
- Mental status that is incompatible with the proper conduct of the study;
- Participation in any scientific study with oral, intravenous or inhalatory administration of any substances during two (2) months before study start that could interfere with the MOIST study;
- Psychiatric disorders;
- Use of anti-anxiety medications or beta-blockers, statins or blood pressure medication;
- Use of antibiotics during the six (6) months prior to study start;
- Use of topical medications in underarm area during 2 weeks prior to study start;
- Recurring infections, boils, abscesses or lymph node enlargement in the underarm and ;
- Active eczema or psoriasis on any portion of the body.
- Personnel of the research institute(s) involved in execution of the study, their partner and their first and second degree relatives;
- Not having a general practitioner, not allowing disclosure of participation to the general practitioner or not allow to inform the general practitioner about abnormal results.
Key Trial Info
Start Date :
October 31 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 17 2018
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03384030
Start Date
October 31 2017
End Date
March 17 2018
Last Update
September 5 2018
Active Locations (1)
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1
NIZO
Ede, Gelderland, Netherlands, 6718ZB