Status:
UNKNOWN
The Antibiotic Rifampin to Reduce High Levels of Blood and Urine Calcium in IIH
Lead Sponsor:
The Hospital for Sick Children
Collaborating Sponsors:
Children's Hospital of Philadelphia
Canadian Institutes of Health Research (CIHR)
Conditions:
Idiopathic Infantile Hypercalcemia - Mild Form
Eligibility:
All Genders
6-17 years
Phase:
PHASE1
Brief Summary
Idiopathic infantile hypercalcemia(IIH) is a rare,genetic disorder of mineral metabolism. Biallelic loss of functions mutations of CYP24A1, the gene encoding the 24-hydroxylase enzyme that represents ...
Detailed Description
Idiopathic infantile hypercalcemia(IIH) is a rare,genetic disorder of mineral metabolism characterized by severe hypercalcemia and/or hypercalciuria, suppressed serum levels of parathyroid hormone (PT...
Eligibility Criteria
Inclusion
- all patients between 6 months- 17 years of age with the clinical phenotype of idiopathic infantile hypercalcemia
- Biochemical evidence of this disorder: Serum calcium\>upper limit of the reference age for range; high, 1,25 (OH)D; reduced PTH, reduced 24,25(OH)2D, and suppresses 24,1,25 (OH)2D, normal serum creatinine, AST, and ALT with or without
- biallelic inactivating mutations of CYP24A1
- mutations in newly published genes which are shown during the course of the study to cause an inappropriate increase in 1,25 (OH)2D
Exclusion
- Allergy to rifampin or related medications
- Pregnancy or breastfeeding
- Significant cardiac, hepatic, or endocrine comorbidities
- Taking any medications/foods known to interact with CYP3A4 or 1,25 (OH)D
- Parents or guardians or subjects who in the opinion of the Investigator may be non compliant with study schedules or procedures
- Other comorbidities considered unsuitable by the investigator, including TB
Key Trial Info
Start Date :
February 22 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2021
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT03384121
Start Date
February 22 2018
End Date
December 31 2021
Last Update
August 31 2021
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8