Status:
UNKNOWN
Assessment of Dialysis Initiation by a Fuzzy Mathematics Equation
Lead Sponsor:
The First Affiliated Hospital of Dalian Medical University
Collaborating Sponsors:
Chinese PLA General Hospital
Fudan University
Conditions:
Chronic Kidney Disease
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
The purpose of this study is to evaluate the impact of the optimal and late initiation of dialysis on the mortality and quality of life in end-stage renal disease (ESRD) patients by the Dialysis Initi...
Detailed Description
The optimal time of dialysis initiation is still controversial. Estimated glomerular filtration rate (eGFR) which is now widely used as the assessment of timing of dialysis is lack of specificity. Som...
Eligibility Criteria
Inclusion
- Have progressive chronic kidney disease with an eGFR less than 15 ml/min/1.73m2 and a DIFE between 30-35
- Expected to commence maintenance hemodialysis as their renal replacement treatment
- Agreeable to randomization
Exclusion
- Acute kidney injury (AKI) or AKI on chronic kidney disease (CKD)
- With the primary disease of systemic lupus erythematosus (SLE) or systemic vasculitis
- Have received or planning to receive a kidney transplant or peritoneal dialysis during the study
- Has a recently diagnosed cancer that was likely to affect survival (except for the following cases: the cancer has been confirmed to be cured or relieved for over 5 years, have had the radical resection for the basal cell carcinoma or squamous carcinoma of skin or carcinoma in-situ of any part of the body )
- Hepatocirrhosis
- Positive test of Human Immunodeficiency Virus (HIV), the hepatitis B virus antigen (HBsAg) or anti-hepatitis C virus antibody (HCV Ab)
- Acute infection within 1 month
- Bad habit which is difficult to withdrawal such as alcohol abuse
- Poor compliance and could not be treated according to the protocol
- Being pregnant, nursing or having a plan for pregnancy
- Life expectancy less than 1 year
- The investigator confirm that should not enroll in the study with any other cases
Key Trial Info
Start Date :
April 14 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 14 2023
Estimated Enrollment :
388 Patients enrolled
Trial Details
Trial ID
NCT03385902
Start Date
April 14 2018
End Date
December 14 2023
Last Update
April 25 2022
Active Locations (1)
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1
the First Affiliated Hospital of Dalian Medical University
Dalian, Liaoning, China, 116011