Status:
COMPLETED
Feasibility of Multi-Spectral Endoscopic Imaging for Detection of Early Neoplasia in Barrett's Oesophagus
Lead Sponsor:
University of Cambridge
Conditions:
Barrett Esophagus
Esophageal Neoplasms
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Multispectral imaging represents an exciting new field of investigation in endoscopic research. Multispectral imaging uses a specialised camera to detect multiple colours, allowing us to build a rough...
Detailed Description
The investigators have developed a custom multispectral endoscopes based around a CE marked device, the PolyScope disposable endoscope (PolyDiagnost). This is a combined sterile catheter and fibre opt...
Eligibility Criteria
Inclusion
- Male or female subjects over 18 years
- Previous diagnosis of Barrett's oesophagus, with an endoscopic length of at least 2 cm
- Previous diagnosis of oesophageal glandular dysplasia or early oesophageal adenocarcinoma for consideration of endoscopic therapy
Exclusion
- History of oesophageal stricture precluding passage of the endoscope,
- Pregnancy, or planned pregnancy during the course of the study,
- Currently breastfeeding
- Any history of esophageal varices, liver impairment of moderate or worse severity (Child's- Pugh class B \& C) or evidence of varices on initial treatment endoscopy,
- Any history of oesophageal surgery, except for uncomplicated fundoplication, and,
- History of coagulopathy, with INR\>1.3 and/or platelet count of \<75,000.
- On clopidogrel, and/or warfarin for high risk condition and unable to withhold temporarily the medication.
Key Trial Info
Start Date :
January 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2020
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT03388047
Start Date
January 1 2018
End Date
December 31 2020
Last Update
April 28 2021
Active Locations (1)
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1
MRC Cancer Unit
Cambridge, United Kingdom, CB2 0XZ