Status:
COMPLETED
Inflammation Impact on Pain in Knee Osteoarthritis
Lead Sponsor:
Sten Rasmussen, MD, PhD
Collaborating Sponsors:
Aalborg University
Conditions:
Inflammation
Osteo Arthritis Knee
Eligibility:
All Genders
40-75 years
Phase:
NA
Brief Summary
The aim of this study is to use gold particles as a model compound to modulate specifically and selectively the function of macrophages and mast cells and investigate how this modulates pain and pain ...
Detailed Description
Osteoarthritis (OA) of the knee and hip is the most common musculoskeletal joint disease worldwide. Although a major symptom of OA is chronic joint pain, which has a significant effect on patients' qu...
Eligibility Criteria
Inclusion
- Knee OA diagnosed based on the American College of Rheumatology criteria, KL (Kellgren-Lawrence) X-ray grade ≧ 2, pain for \> 3months, maximal pain intensity VAS (visual analogue scale) ≧ 5 (0-10 scale) for the most painful knee during the last week. Knee joint effusion that can be aspirated
Exclusion
- Pregnancy
- Drug addiction defined as the use of cannabis, opioids or other drugs
- Previous neurologic, musculoskeletal or mental illnesses
- Lack of ability to cooperate
- Current use of medications that may affect the trial e.g. analgesics, anti-inflammatory drugs
- Recent history of acute pain affecting the lower limb and/or trunk
- Past history of a chronic pain condition
- Participation in other pain trials throughout the study period
Key Trial Info
Start Date :
December 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2020
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT03389906
Start Date
December 1 2017
End Date
December 1 2020
Last Update
August 12 2021
Active Locations (1)
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1
Aalborg University Hospital
Aalborg, Denmark, 9000