Status:
ACTIVE_NOT_RECRUITING
Effects of Negative Affect in Individuals With Binge Eating Episodes
Lead Sponsor:
University of California, San Diego
Collaborating Sponsors:
Sanford Research
University of Colorado, Denver
Conditions:
Bulimia Nervosa
Binge-Eating Disorder
Eligibility:
All Genders
18-55 years
Phase:
NA
Brief Summary
Binge-eating is characterized by recurrent episodes of eating large amounts of - typically high calorie - foods, eating much more rapidly than normal and until feeling uncomfortably full, as well as f...
Detailed Description
Specific Aim 1: To test on two study days, one neutral affect and one negative affect day (affect induction) whether negative affect alters brain reinforcement learning in a dopamine system anchored t...
Eligibility Criteria
Inclusion
- Healthy Controls
- Age 18-55 years old
- Healthy body weight between 90 and 110 % average body weight since puberty.
- Regular monthly menstrual cycle (if applicable)
- Edinburgh Handedness Inventory Revised (EHI-R) LQ\* score \> +200
- Obese
- Age 18-55 years old
- Current body mass index (BMI) \> 30 kg/m2.
- Stable food intake regimen in previous 4 weeks.
- Edinburgh Handedness Inventory Revised (EHI-R) LQ\* score \> +200
- Obese for at least one year
- Binge Eating Disorder
- Age 18-55 years old
- Edinburgh Handedness Inventory Revised (EHI-R) LQ\* score \> +200
- DSM 5 diagnosis of Binge Eating Disorder A. Recurrent episodes of binge eating B. Binge eating episodes are associated with three (or more) of the following
- Eating much more rapidly than normal.
- Eating until feeling uncomfortably full.
- Eating large amounts of food when not feeling physically hungry.
- Eating alone because of embarrassment.
- Feeling disgusted with oneself, depressed, or very guilty after overeating. C. Marked distress regarding binge eating is present. D. At least once a week for 3 months. E. The binge eating is not associated with the recurrent use of inappropriate compensatory behavior.
- Bulimia Nervosa
- Age 18-55 years old
- Edinburgh Handedness Inventory Revised (EHI-R) LQ\* score \> +200
- DSM 5 diagnosis of Bulimia Nervosa A. Recurrent episodes of binge eating Eating, in a discrete period of time, an amount of food that is definitely larger than most people would eat during a similar period of time and under similar circumstances.
- A sense of lack of control over eating during the episode. B. Recurrent inappropriate compensatory behavior in order to prevent weight gain, such as self-induced vomiting; misuse of laxatives, diuretics, or other medications; fasting; or excessive exercise.
- C. At least once a week for 3 months. D. Self-evaluation is unduly influenced by body shape and weight.
Exclusion
- Healthy Controls
- Current pregnancy or breast feeding within last 3 months
- First degree relative with current or past eating disorder
- Current Medications other than BCP or IUD
- Past or present Axis I psychiatric disorder including substance or alcohol use disorder as determined through SCID-5 clinical interview
- First degree relative with an eating disorder
- Major Medical illness
- Recent history of suspected substance abuse or a lifetime history of psychostimulant abuse and/or dependence
- Metal implants or braces
- Obese
- Current pregnancy or breast feeding within last 3 months
- First degree relative with current or past eating disorder
- Current or previous eating disorder diagnosis
- Current Medications other than BCP or IUD
- Past or present Axis I psychiatric disorder including substance or alcohol use disorder as determined through SCID-5 clinical interview
- Major Medical illness
- Recent history of suspected substance abuse or a lifetime history of psychostimulant abuse and/or dependence
- Metal implants or braces
- Binge Eating Disorder
- Pregnancy or breast feeding within last 3 months
- Lifetime history of bipolar disorder or psychosis
- Use of a psychostimulant within the prior 6 months
- Recent history of substance abuse or dependence (except for alcohol and cannabis use)
- Major Medical illness
- Metal implants or braces
- Bulimia Nervosa
- Pregnancy or breast feeding within last 3 months
- Lifetime history of bipolar disorder or psychosis
- Use of a psychostimulant within the prior 6 months
- Recent history of substance abuse or dependence (except for alcohol and cannabis use)
- Major Medical illness
- Metal implants or braces
Key Trial Info
Start Date :
February 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2026
Estimated Enrollment :
410 Patients enrolled
Trial Details
Trial ID
NCT03393039
Start Date
February 1 2018
End Date
June 30 2026
Last Update
September 2 2025
Active Locations (1)
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1
University of California at San Diego
San Diego, California, United States, 92121