Status:
COMPLETED
Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment for Obsessive Compulsive Disease
Lead Sponsor:
Anhui Medical University
Conditions:
Obsessive-Compulsive Disorder
Transcranial Magnetic Stimulation
Eligibility:
All Genders
18-50 years
Phase:
NA
Brief Summary
To investigate the treatment effect of repetitive transcranial magnetic stimulation on Obsessive-compulsive disorder, and the underlying neural mechanism by functional MRI.
Detailed Description
All patients underwent a medical evaluation that included physical examination and routine laboratory studies before and after repetitive transcranial magnetic stimulation (rTMS) treatment. Patients w...
Eligibility Criteria
Inclusion
- Patients met diagnostic criteria for obsessive-compulsive disorder using The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)，confirmed by two clinical psychiatrist.
- Y-BOCS total severity scores ≥16（Simple forced obsessions or compulsions ≥ 10），HAMA-14 scores \< 14，HAMD-17 scores \< 17； Raven's Standard Progressive Matrices（SPM） up to normal levels.
- After more than one anti-OCD drugs treatment for 8-10 weeks, no significant improvement in symptoms.
- Voluntarily participated and cooperated with the experiment.
Exclusion
- \- History of significant head trauma or neurological disorders. Alcohol or drug abuse. Organic brain defects on T1 or T2 images. History of seizures or unexplained loss of consciousness. Family history of medication refractory epilepsy. recent aggression or other forms of behavioral dyscontrol.
Key Trial Info
Start Date :
August 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2020
Estimated Enrollment :
37 Patients enrolled
Trial Details
Trial ID
NCT03393078
Start Date
August 1 2017
End Date
December 1 2020
Last Update
January 4 2022
Active Locations (1)
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1
Anhui Medical University
Hefei, Anhui, China, 230032