Status:
COMPLETED
ECG-I Phenotyping of Persistent AF Based on Driver Distribution to Predict Response to Pulmonary Vein Isolation
Lead Sponsor:
Barts & The London NHS Trust
Conditions:
Atrial Fibrillation
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Atrial fibrillation (AF) is an irregular heart rhythm associated with significant morbidity and mortality. The pulmonary veins (the blood vessels carrying blood from the lungs into the left atrium) ha...
Detailed Description
Atrial Fibrillation (AF) is the commonest heart rhythm disturbance and is associated with significant morbidity and mortality. Catheter ablation (CA) is a procedure where catheters (leads) are passed ...
Eligibility Criteria
Inclusion
- Patients diagnosed with Persistent AF (i.e. episodes of AF that are continuous for \> 1 week or have required DC cardioversion)
- Willing for ablation.
- Age between 18 to 80.
- left atrial diameter \<5 cm
- left ventricular function \>40%.
- New York Heart Association class \< 3.
Exclusion
- Persistent AF diagnosed \> 2 years ago
- left atrial diameter \> 5 cm
- Severe left ventricular impairment (EF \< 40%)
- New York Heart Association class 3 or 4 heart failure
- Known hypertrophic cardiomyopathy, cardiac sarcoid, or arrythmogenic ventricular cardiomyopathy.
- Known inherited arrhythmia such as Brugada or long QT syndromes
- Valvular disease that is more than moderate
- History of valve replacement (metallic or tissue)
- History of congenital heart disease (other than patent foramen ovale)
- Previous left atrial ablation (percutaneous or surgical)
- Cardiac surgery or percutaneous coronary intervention within the last 3 months.
- Myocardial infarction or unstable angina within the last 3 months.
- Unwillingness for ablation
- Unwillingness to be involved in study
- Suspected reversible cause of AF
- Any other contraindication to catheter ablation
- Age \< 18 yrs or \> 80 years
- Pregnancy
- Morbid obesity (defined as BMI \>40)
- Any other medical problem likely to cause death within the next 18 months
Key Trial Info
Start Date :
January 8 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 31 2021
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT03394404
Start Date
January 8 2018
End Date
March 31 2021
Last Update
October 22 2024
Active Locations (1)
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1
Barts Heart Centre
London, United Kingdom, EC1A 7BE