Status:
TERMINATED
Ketamine in Borderline Personality Disorder
Lead Sponsor:
Yale University
Collaborating Sponsors:
Nathan Kline Institute for Psychiatric Research
American Foundation for Suicide Prevention
Conditions:
Borderline Personality Disorder
Eligibility:
All Genders
21-60 years
Phase:
PHASE2
Brief Summary
The purpose of this study is to test the potential of the rapid-acting anti-depressant ketamine to decrease suicidality in Borderline Personality Disorder (BPD). The rate of completed suicide in BPD ...
Detailed Description
This clinical trial primarily tests the impact of ketamine on suicidal thoughts in Borderline Personality Disorder (BPD). It also tests the impact of ketamine on symptom intensity (for mood, BPD, and ...
Eligibility Criteria
Inclusion
- Age 21-60
- Clinical diagnosis of Borderline Personality Disorder
- Has suicidal ideation.
- Fluent in English
- Has a current mental health treater, and agrees for study to communicate with treater
Exclusion
- Current suicidal intent
- Med changes in last 4 weeks
- Any ketamine in any context in the last one year.
- Current prescription for topiramate, lamotrigine, or lithium.
- Psychotic disorder in self or first-degree relative
- Current substance dependence including alcohol dependence
- Any history of NMDA (N-methyl-D-aspartate )-antagonist abuse
- Any history of opiate abuse
- History of major medical illness especially neurologic or cardiovascular condition, or any other medical contra-indication to ketamine administration at the discretion of the study MD.
- Positive urine test for drugs of abuse screening on day of ketamine administration
- Positive pregnancy test on day of ketamine administration
- At the discretion of study staff
Key Trial Info
Start Date :
February 15 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 6 2022
Estimated Enrollment :
22 Patients enrolled
Trial Details
Trial ID
NCT03395314
Start Date
February 15 2018
End Date
May 6 2022
Last Update
June 26 2023
Active Locations (2)
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1
Connecticut Mental Health Center
New Haven, Connecticut, United States, 06519
2
Yale New Haven Hospital
New Haven, Connecticut, United States, 06519