Status:
COMPLETED
Uric Acid Effects on Endothelium and Oxydative Stress
Lead Sponsor:
Erasme University Hospital
Collaborating Sponsors:
Fonds Erasme
Fonds National de la Recherche Scientifique
Conditions:
Oxidative Stress
Endothelial Function
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Cardiovascular disease is the leading cause of mortality worldwide. Endothelial dysfunction (ED) is the main mechanism which leads to atherosclerosis, where the balance between pro and antioxidant fac...
Detailed Description
The goals of the research protocol are to clearly untie the respective roles of uric acid (UA) and xanthine oxidoreductase (XOR) pathways on endothelial function and oxidative stress in humans. UA re...
Eligibility Criteria
Inclusion
- Phase 1 :
- Age between 18 and 40 years
- Male
- Healthy volunteers
- Non smoker for at least 6 months
- Uric acid level in normal range (normouricemic group)
Exclusion
- Any diseases of one of the following systems: cardiovascular, digestive, hormonal, urinary, pulmonary, rheumatic or immune.
- Smoker, alcoholic
- Participants should not take any chronic medicine nor vitamins or other antioxidants.
- A G6PD deficit will be excluded as this is a contraindication to uricase administration (hemolytic anemia).
- Phase 2 :
- Inclusion Criteria:
- Age between 40 and 65 years
- Male or female (menopaused)
- Healthy volunteers
- Non smoker for at least 6 months
- Uric acid level in normal range (normouricemic group)
Key Trial Info
Start Date :
January 3 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 27 2020
Estimated Enrollment :
53 Patients enrolled
Trial Details
Trial ID
NCT03395977
Start Date
January 3 2018
End Date
February 27 2020
Last Update
February 28 2020
Active Locations (1)
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1
Erasme Hospital
Brussels, Belgique, Belgium, 1070