Status:
RECRUITING
Biology of Juvenile Myoclonic Epilepsy
Lead Sponsor:
King's College London
Collaborating Sponsors:
King's College Hospital NHS Trust
Charles University, Czech Republic
Conditions:
Juvenile Myoclonic Epilepsy
Eligibility:
All Genders
10-40 years
Brief Summary
The investigators are collecting genetic information through blood samples as well as clinical and EEG data from over 1000 people with Juvenile Myoclonic Epilepsy (JME) across the UK, Europe and North...
Detailed Description
Epilepsy is a common neurological disorder affecting 1% of the population. There are over 30 types of epilepsy, some common, some rare. Most epilepsies arise in childhood and have a genetic cause. App...
Eligibility Criteria
Inclusion
- Diagnosis of Juvenile Myoclonic Epilepsy in accordance with Consensus criteria
- Age of myoclonus onset 10-25 years
- Seizures comprising predominant or exclusive early morning myoclonus of upper extremities
- EEG interictal generalized spikes and/or polyspike and waves with normal background
- Current age 10-40 years
Exclusion
- Myoclonus only associated with carbamazepine or lamotrigine therapy
- EEG showing predominant focal interictal epileptiform discharges or abnormal background
- Any evidence of progressive or symptomatic myoclonus epilepsy or focal seizures
- Global learning disability
- Dysmorphic syndrome
- Unable to provide informed consent
- Regrettably, we are currently unable to accept self-referrals to the BIOJUME study.
Key Trial Info
Start Date :
July 13 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2026
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT03400371
Start Date
July 13 2017
End Date
December 31 2026
Last Update
September 5 2025
Active Locations (15)
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1
Mount Sinai-Beth Israel Medical Center
New York, New York, United States, 10003
2
St Luke's Roosevelt Hospital
New York, New York, United States, 10025
3
Nationwide Children's Hospital
Columbus, Ohio, United States, 43125
4
Hospital for Sick Kids
Toronto, Ontario, Canada, M5G 0A4