Status:
WITHDRAWN
The Diversity of Intestinal Microbiota in Patients With Different Sedative-hypnotics Undergoing Mechanical Ventilation
Lead Sponsor:
Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Conditions:
Intestinal Microbiota
Mechanical Ventilation
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Bidirectional communication between the CNS and the GI tract - the brain-gut axis - occurs both in health and disease.Patients with mechanical ventilation in ICU (ICU) often meet the necessary nutriti...
Detailed Description
There are a variety of normal microbial communities in the healthy human intestines, which maintain the physiological balance of the host. Under normal circumstances, there are about 104 intestinal mi...
Eligibility Criteria
Inclusion
- patients who receive long-term (≥12 hours) mechanical ventilation after operation on admission to the ICU
- APACHEII score 12-20 points
- no receive other clinical trials in the near 3 months
- no acute infectious disease, psychosis or other disease
- volunteer people
Exclusion
- known or suspected allergy to midazolam or Dexmedetomidine
- suspected pregnancy, gross obesity, hyperlipemia, moribund state
- history of alcoholism or intake of anti-anxiety drugs or hypnotics
- chronic renal failure
- coma by cranial trauma or neurosurgery or unknown etiology or status epilepticus
- unwillingness to provide informed consent by patients or their authorized surrogates following ICU admission.
Key Trial Info
Start Date :
March 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2020
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT03401736
Start Date
March 1 2018
End Date
November 1 2020
Last Update
September 28 2021
Active Locations (1)
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1
Shanghai9 Hospital
Shanghai, Shanghai Municipality, China