Status:
COMPLETED
Retinal Neuro-vascular Coupling in Patients With Non-arteritic Anterior Ischemic Optic Neuropathy
Lead Sponsor:
Medical University of Vienna
Conditions:
Anterior Ischemic Optic Neuropathy
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Ischemic optic neuropathy is among the most common causes of serious impaired vision in the middle-aged and elderly population in the western world. The current study focuses on a subgroup of ischemic...
Eligibility Criteria
Inclusion
- Inclusion criteria for healthy subjects:
- Men and women aged over 18 years
- Non-smokers
- Normal findings in the medical history unless the investigator considers an abnormality to be clinically irrelevant
- Normal ophthalmic findings, ametropy \< 6 Dpt.
- Inclusion criteria for patients with NAION:
- Men and women aged over 18 years
- History of NAION in one eye
- Normal ophthalmic findings, ametropy \< 6 Dpt.
- Adequate visual acuity to allow participation in the ocular blood flow measurements
- A potential participant has to be on stable doses of all medications he/she is taking because of consisting illnesses according to medical history for at least 30 days prior inclusion, if considered relevant by the investigator.
- Any of the following will exclude a healthy subject from the study:
- Current ocular disease or history of NAION
- Presence or history of a severe medical condition as judged by the clinical investigator
- Untreated Arterial hypertension
- History or family history of epilepsy
- Presence of any abnormalities preventing reliable measurements in the study eye as judged by the investigator
- Best corrected visual acuity \< 0.5 Snellen
- Ametropy ≥ 6 Dpt
- Pregnancy or planned pregnancy
- Alcoholism or substance abuse
- Any of the following will exclude a patient from the study:
- Presence or history of a severe medical condition other NAION as judged by the clinical investigator
- Untreated Arterial hypertension
- History or family history of epilepsy
- Presence of any abnormalities preventing reliable measurements in the study eye as judged by the investigator
- Best corrected visual acuity \< 0.5 Snellen in the non-affected eye
- Ametropy ≥ 6 Dpt
- Pregnancy, planned pregnancy
- Alcoholism or substance abuse
Exclusion
Key Trial Info
Start Date :
June 11 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 11 2018
Estimated Enrollment :
1 Patients enrolled
Trial Details
Trial ID
NCT03401892
Start Date
June 11 2018
End Date
June 11 2018
Last Update
September 1 2021
Active Locations (1)
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1
Department of Clinical Pharmacology, Medical University of Vienna
Vienna, Austria, 1090