Status:
COMPLETED
Preoperative High Dose Steroids for Liver Resection- Effect on Complications in the Immediate Postoperative Period
Lead Sponsor:
Rigshospitalet, Denmark
Conditions:
Complication, Postoperative
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
Background: Several randomized clinical trials have shown beneficial effects of pre-operative glucocorticoids on post-operative complications. Studies on the effects of glucocorticoids on the postop...
Detailed Description
Post-surgery, patients are traditionally observed and treated in post-anesthesia care units (PACU) until they are discharged to the ward (or directly home) assessed by standardized international disch...
Eligibility Criteria
Inclusion
- Age minimum 18
- Planned open liver resection (with or without combined ablation and/or
- cholecystectomy)
- Able to participate (self report pain/nausea)
- Understands danish/english, or has an interpreter during admission
- Signed consent form
Exclusion
- ALPPS (Associating Liver Partition and Portal vein Ligation for Staged hepatectomy) procedure
- Combined ventral herniotomy with implantation of mesh
- Combined with operation on tumor in other organs
- Insulin dependent diabetes
- Current (\<10 days) treatment with systemic glucocorticoids and/or immunosuppressive treatment (not including inhalations)
- Epidural anesthesia not feasible
- Pregnancy/breastfeeding
- Allergy toward study medication
- Inoperability
Key Trial Info
Start Date :
December 11 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 28 2020
Estimated Enrollment :
174 Patients enrolled
Trial Details
Trial ID
NCT03403517
Start Date
December 11 2017
End Date
September 28 2020
Last Update
January 5 2021
Active Locations (1)
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1
Rigshospitalet
Copenhagen, Denmark, 2100