Status:
UNKNOWN
Safety and Efficacy of Recombinant Anti-EGFR Monoclonal Antibody in Patients With Wild-type RAS and BRAF mCRC
Lead Sponsor:
Sinocelltech Ltd.
Collaborating Sponsors:
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Conditions:
Metastatic Colorectal Cancer
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The purpose of this study is to evaluate the efficacy and safety of recombinant anti-EGFR Monoclonal antibody（SCT200）in patients with wild-type RAS and BRAF mCRC treated with fluorouracil, oxaliplatin...
Eligibility Criteria
Inclusion
- Able to provide written informed consent and can understand and comply with the requirements of the study;
- Men and women ≥ 18 years of age;
- Life expectancy of longer than 3 months ( clinical assessment);
- With an Eastern Cooperative Oncology Group (ECOG) performance status of ≤ 1;
- Have been diagnosed as mCRC verified histologically;
- Patients treated with fluorouracil, oxaliplatin and irinotecan after failure of standard therapy. Disease progressed or developed non-tolerable toxicity after systemic chemotherapy：a. at least one treatment cycle should be completed, and maintenance therapy using one of the doublets is considered as the same line of therapy ; b. May have received adjuvant therapy for primary colorectal cancer provided that at least 6 months have elapsed from the time the adjuvant therapy was concluded and recurrent disease was documented;
- RAS and BRAF wildtype status of primary colorectal cancer or related metastasis;
- Adequate organ and marrow function as defined below:
- Absolute neutrophil count (ANC) greater than/equal to 1.5×l09/L; Platelets greater than/equal to 75×109/L; Hemoglobin greater than/equal to 80g/L; Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) less than/equal to 2.5 times IULN, or less than/equal to 5 times IULN if known liver metastases; Total bilirubin less than/equal to 1.5 within institutional upper limit of normal (IULN); Serum creatinine less than/equal to 1.5 times IULN; Electrolyte: magnesium greater than/equal to normal.
- According to RECIST 1.1 , patients must have at least one measurable lesion that can be accurately assessed at baseline and is suitable for repeated assessment by CT, MRI. Longest diameter greater than/equal to10mm（CT scan slice thickness no greater than 5 mm）, a lymph node must be ≥15mm in short axis when assessed by CT scan.
Exclusion
- Patient with active brain metastasis or indicated for symptomatic treatment for brain metastasis, untreated with proper radiation therapy, showing clinical symptoms or symptom stable time less than 28 days;
- Patients with other primary malignancies within the past 5 years except non-melanoma skin cancer, carcinoma in situ of cervix or prostatic intraepithelial neoplasia;
- Patients who are allergic to analogue of SCT200 and/or its inactive ingredients;
- Patients administrated EGFR target treatment including EGFR TKI agent or anti- EGFR monoclonal antibody;
- Within 4 weeks, patients received anti-tumor drugs (such as chemotherapy, hormone therapy, immune therapy, the antibody therapy, radiotherapy) or research drugs, or patients with grade 2 or more adverse reaction caused by previous anti-tumor therapy(except alopecia or neurotoxicity grade 2 or less);
- Patients are currently enrolled in other research devices or in research drugs, or less than 4 weeks from other research drugs or devices.
- Patients received major surgery(such as need general anesthesia ) within 4 weeks , should recover from the injury associated with the surgery.
- Patients treated with EPO, G-CSF or GM-CSF.
- Patients who have clinically significant cardiovascular disease (defined as unstable angina pectoris, symptomatic congestive heart failure (NYHA, greater than II), uncontrollable severe arrhythmia);
- Patients occurred myocardial infarction within 6 months.
- Patients who have interstitial lung disease, such as interstitial pneumonia, pulmonary fibrosis, or CT or MRI reminder ILD .
- Patients with clinical symptoms, required clinical intervention or stable time less than 4 weeks of serous cavity effusion (such as pleural effusion and ascites);
- Patients with serious psychological or psychiatric disorders which may affect subject compliance in this clinical study;
- Pregnant or lactating women, or women who planned to be pregnant within 6 months of treatment;
- Patients who were not willing to accept effective contraceptive measures (including male or female subjects) during treatment and within 6 months after treatment;
- Patients with active hepatitis B or active hepatitis C, etc. (for patients with a history of hepatitis B, whether treated or not, HBV DNA ≥104 or ≥ 2000IU/ml, HCV RNA≥15IU/ml); HIV antibody positive (if there is no clinical evidence suggesting that there may be HIV infection, there is no need to detect);
- Patients with uncontrolled active infections before enrollment 2 weeks (except simple urinary tract infection or upper respiratory tract infection);
- Patients have alcohol or drug addiction;
- Inability to comply with study and/or follow-up procedures
Key Trial Info
Start Date :
February 12 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2019
Estimated Enrollment :
110 Patients enrolled
Trial Details
Trial ID
NCT03405272
Start Date
February 12 2018
End Date
December 1 2019
Last Update
January 23 2018
Active Locations (21)
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1
The First Affiliated Hospital of Anhui Medical University
Hefei, Anhui, China
2
Cancer hospital Chinese academy of medical sciences
Beijing, Beijing Municipality, China
3
Chinese PLA General Hospital
Beijing, Beijing Municipality, China
4
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China