Status:
COMPLETED
Sleep, Wake and Light Therapy for Depression
Lead Sponsor:
King's College London
Collaborating Sponsors:
Kings Health Partners
Conditions:
Depression
Depressive Disorder, Major
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The aim of this study is to determine if altering the pattern of one's sleep and having light therapy can speed up the treatment of depression. In the UK, the large majority of patients with depressio...
Detailed Description
* Participants will be given a wristband (Actigraph) * Participants will be asked to complete various questionnaires and be interviewed at 1 week, 2 weeks, 4 weeks, 8 weeks and at 6 months after start...
Eligibility Criteria
Inclusion
- Diagnosis of Depressive Episode (ICD10 F32) or Recurrent Depressive Disorder (F33).
- Minimum score of 8 or more on the Hamilton Depression Rating Scale (6 item) (Range 0-22) (Bech,1981).
- Age 18-65
- Able to give informed consent
- Women of child bearing age may be included and no methods of contraception is required to enable inclusion into the trial.
Exclusion
- Current diagnosis of Seasonal Affective Disorder
- Current diagnosis of anorexia nervosa or bulimia.
- Current diagnosis of an obsessive compulsive or related disorder
- Current diagnosis of post-traumatic stress disorder
- History of schizophrenia, schizoaffective disorder or bipolar disorder
- Severe cognitive impairment, dementia, intellectual disability or organic brain disorder.
- History of stimulant or hallucinogenic misuse, alcohol or substance misuse or dependence in past 3 months.
- Borderline Personality Disorder or other personality disorder considered to be the main problem.
- Duration of depression more than 2 years.
- Significant risk of suicide that requires hospitalisation.
- Severe eye disease or cataracts or traumatic injury or visual impairment affecting both eyes.
- History of epilepsy, uncontrolled severe headaches, or stroke as this may lower seizure threshold through sleep deprivation.
- Unstable medical condition that would make wake therapy intolerable
- Untreated sleep disorder such as obstructive sleep apnoea or narcolepsy
- Use of photo-sensitizing drugs.
- Current night-shift work.
- Non-English speaker.
Key Trial Info
Start Date :
January 18 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 23 2019
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT03405493
Start Date
January 18 2018
End Date
September 23 2019
Last Update
September 26 2019
Active Locations (1)
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1
South London and Maudsley NHS Foundation Trust
London, United Kingdom