Status:
COMPLETED
High Intensity Interval Training and Skeletal Muscle Insulin Sensitivity
Lead Sponsor:
Maastricht University
Collaborating Sponsors:
Netherlands Organisation for Scientific Research
Conditions:
Overweight and Obesity
Eligibility:
All Genders
45-75 years
Phase:
NA
Brief Summary
This human intervention study will test if 12 weeks of supervised HIIT-based intervention improves skeletal muscle NOGD capacity in obese subjects.
Detailed Description
19 overweight-obese (BMI =\> 27kg/m2), sedentary females and males aged 45-75yr will be enrolled in this study. Participants will train 3 times/week under supervision during 12 weeks. Before, after a...
Eligibility Criteria
Inclusion
- Signed informed consent
- Age 45 - 75 years old
- Overweight to obese (BMI =\> 27kg/m2)
- Sedentary - subjects do not perform any regular physical activity weekly(\<3 times per week, \<150 min/week).
Exclusion
- Unstable body weight (weight gain or loss \> 3 kg in the past three months)
- Participation in an intensive weight-loss program or in vigorous exercise program during the last year before starting the study.
- HbA1c \> 6.5% and glucose clearance rate \>350 ml/kg/min (by OGTT).
- Previously diagnosed with type 2 diabetes
- Active cardiovascular disease. This will be determined by the questionnaires and by screening on medication.
- Use of beta-blockers
- Anticoagulant therapy
- Systolic blood pressure \>160 mmHg or diastolic blood pressure \>100 mmHg
- Abuse of alcohol (\> 3 units (1 unit = 10 gr ethanol) per day)
- Any contra-indication to Magnetic Resonance Imaging (MRI) scanning
- Participation in another biomedical study within 1 month before the first study visit, which may interfere with the outcomes of the present study.
- Use of any medication affecting the glucose homeostasis and whole body metabolism or diseases that may significantly interfere with the main aim of the study.
- Chronic renal dysfunction (creatinine \>2 increased (normal value 64-104 µmol/l)
- Subjects who do not want to be informed about unexpected medical findings during the screening / study, or do not wish that their physician is informed, cannot participate in the study.
- Subjects will be included only when the dependent medical doctor of this study approves participation after evaluating all data obtained during the screening.
Key Trial Info
Start Date :
March 28 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2021
Estimated Enrollment :
19 Patients enrolled
Trial Details
Trial ID
NCT03405545
Start Date
March 28 2018
End Date
October 1 2021
Last Update
September 14 2022
Active Locations (1)
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1
University Maastricht
Maastricht, Limburg, Netherlands, 6229ER