Status:
WITHDRAWN
Modulation of Episodic Memory Using Theta Burst Stimulation (TBS)
Lead Sponsor:
Duke University
Conditions:
Aging
Eligibility:
All Genders
60-80 years
Phase:
NA
Brief Summary
The goal of this study is to evaluate the effect of white matter guided theta burst stimulation on episodic memory task performance in healthy older adults. The investigators aim to propagate the effe...
Detailed Description
Aims and Hypotheses The purpose of the study is to evaluate the effect of theta burst stimulation (TBS) which is a relatively new paradigm of transcranial magnetic stimulation (TMS) on episodic memory...
Eligibility Criteria
Inclusion
- Healthy controls in the age group 60-80 years old
- No other Diagnostic and Statistical Manual of Mental Disorders (DSM) 5 axis 1 diagnoses
- Willing to provide informed consent
- Structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) data available
Exclusion
- Subjects are unable or unwilling to give informed consent
- Presence of any organic brain illness
- Presence or history of stroke, traumatic brain injury or head injury with loss of consciousness, transient ischemic attack (TIA), any diagnosed neurological disorder including but not limited to multiple sclerosis, Huntington's disease, Parkinson's disease, dementia or major neurocognitive disorder.
- Presence of cranial metal implants, structural brain lesion including but not limited to cerebral aneurysms.
- Presence of devices that may be affected by repetitive transcranial magnetic stimulation (rTMS) (pacemaker, medication pump, cochlear implant, implanted brain stimulator)
- Current or recent (within the past 6 months) substance abuse or dependence, excluding nicotine and caffeine.
- Current serious medical illness
- History of seizure except those therapeutically induced by electroconvulsive therapy (ECT) (childhood febrile seizures are acceptable and these subjects may be included in the study), history of epilepsy in self or first degree relatives
- For subjects age \> 59 years, a total scaled score \< 8 on the Dementia Rating Scale-2.
Key Trial Info
Start Date :
December 15 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 30 2019
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT03406195
Start Date
December 15 2018
End Date
December 30 2019
Last Update
September 6 2018
Active Locations (1)
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1
Duke University Medical Center
Durham, North Carolina, United States, 27710