Status:
COMPLETED
Misoprosotol and Isosorbide Mononitrate for Induction of Second Trimester Abortion
Lead Sponsor:
Ain Shams University
Conditions:
Second Trimester Abortion
Eligibility:
FEMALE
16-40 years
Phase:
PHASE4
Brief Summary
the investigators aimed to study the efficacy and safety of nitric oxide donors when combined with prostaglandins in induction of second trimester abortion expecting that both drugs when used together...
Detailed Description
the study aimed to compare the effect of isosorbid mononitrate when combined with misoprostol and misoprostol when used alone in second trimester abortion, expecting that both drugs when used together...
Eligibility Criteria
Inclusion
- Age 16 -40 years
- Missed abortion
- Singelton pregnancy
- Gestationl age between 13 and 26 weeks of pregnancy
- Normal uterus and cevix on clinical examination
- Cervix is not dilatated
- No uterine activity and vaginal bleeding
- Written and informed consent by the patient
- Unscarred uterus
Exclusion
- Presence of uterine contraction or bleeding
- Evidences suggesting of onset of spontaneous abortion as Previous trial to induce abortion
- Multifetal pregnancy
- Suspicion of septic abortion
- History of cervical surgery or manipulation
- Uterine anomaly
- IUD in situ
- Associtaed hemorrhagic disorder
- History of adverse effects to vaginally adminstered medication
- Inability to insert vaginal medication high in vagina
Key Trial Info
Start Date :
April 12 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 15 2017
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT03407521
Start Date
April 12 2017
End Date
December 15 2017
Last Update
February 28 2018
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Faculty of Medicine Ain Shams University
Cairo, Egypt, 11566