Status:
COMPLETED
The Influence of Skin Pigmentation on UVB Induced Vitamin D Increase
Lead Sponsor:
Bispebjerg Hospital
Collaborating Sponsors:
Rigshospitalet, Denmark
Conditions:
Healthy Volunteers
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Skin pigmentation (melanin) absorbs ultra violet type B (UVB) radiation found in sunlight and is believed to be responsible for darker-skinned persons' generally low 25(OH)D status. This phenomenon is...
Detailed Description
Background. Melanin molecules (pigment) in skin, absorb UVB and presumably reduce the photo-conversion of 7-dehydrocholesterol. Epidemiological studies have reported poor vitamin D status in relativel...
Eligibility Criteria
Inclusion
- Fitzpatrick Skin type I-IV (light-skinned)
- Fitzpatrick Skin type V-VI (darker-skinned).
Exclusion
- Vitamin D supplementation exceeding 10 µg/day one month prior to study start
- Vitamin D supplementation during study period
- Sun holiday south of latitude 45 degrees N one month prior to or during the study start
- Use of solarium one month prior to or during the study period
- Chronic disease
- Skin disease
- Intake of cholesterol-lowering or photosensitising medication
- Pregnancy
- Drug addiction
- Psychiatric disorder
- Physical disabilities.
Key Trial Info
Start Date :
November 1 2010
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 25 2011
Estimated Enrollment :
43 Patients enrolled
Trial Details
Trial ID
NCT03409510
Start Date
November 1 2010
End Date
June 25 2011
Last Update
January 31 2018
Active Locations (1)
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1
Department of Dermatology, D92, Bispebjerg Hospital
Copenhagen NV, Denmark, 2400