Status:
UNKNOWN
The Brain Changes in Sleep Apnea Study
Lead Sponsor:
Dr. Andrew Lim
Collaborating Sponsors:
University of Edinburgh
Conditions:
Sleep
Sleep Apnea
Eligibility:
All Genders
18+ years
Brief Summary
Sleep is critical to human health, but insufficient and disrupted sleep caused by sleep apnea are common and have a major impact on brain health. However, there is still much that is not known about h...
Detailed Description
Between January 2018 and February 2022, the Brain Changes in Sleep Apnea Study will recruit 80 adults with newly diagnosed severe sleep apnea attending the sleep clinics at Sunnybrook Health Sciences ...
Eligibility Criteria
Inclusion
- Newly diagnosed sleep apnea not on CPAP or any other treatment for sleep apnea;
- Apnea hypopnea index \>=15 on diagnostic polysomnogram;
- Oxygen desaturation index \>=10 or O2 saturation in sleep \<90% for \>15 minutes on diagnostic polysomnogram;
- Subjectively sleepy;
- Planning on starting CPAP for sleep apnea.
Exclusion
- Known history of stroke, transient ischemic attack, or other CNS disease;
- Unable to safely undergo MRI;
- Use of alpha-blocking agents;
- Persistent non-sinus arrhythmia;
- Severe pulmonary or cardiac diseases including COPD and CHF;
- Waking spO2\<90%;
- History of panic disorder.
Key Trial Info
Start Date :
December 12 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 15 2022
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT03410095
Start Date
December 12 2018
End Date
June 15 2022
Last Update
March 22 2021
Active Locations (1)
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1
Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada, M4N3M5