Status:
COMPLETED
Cartilage Adaptation and Response to Interleukins and Exercise
Lead Sponsor:
Bispebjerg Hospital
Conditions:
Osteo Arthritis Knee
Eligibility:
All Genders
40-90 years
Phase:
NA
Brief Summary
This study will examine the effect of exercise on the turnover of collagen in articular cartilage and the content of cytokines in the synovial fluid from human adults with osteoarthritis.
Detailed Description
By using stabile isotope labelling, this study will track the formation and destination of newly formed cartilage collagen in adult humans scheduled for knee replacement surgery due to osteoarthritis....
Eligibility Criteria
Inclusion
- Primary osteoarthritis of the knee scheduled for knee replacement surgery
- Must be able to perform physical exercise
- Age 40-90 years old
- BMI 18.5-40 kg/m\^2
- None smoker for the last 6 weeks
Exclusion
- Regular intake of:
- non steroid anti-inflammatory drugs (NSAID)
- corticoid-steroids
- disease modifying anti-rheumatic drugs (DMARD)
- cytostatic incl. chemotherapy
- immune suppressive medicine
- Inflammatory diseases or cancer
- Recent trauma to the knee (\< 3 months)
- Previous knee surgery
- Regular strenuous exercise ( \> 1 pr. month)
- Previous exposure to tracers (e.g. from another study)
Key Trial Info
Start Date :
February 21 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 10 2019
Estimated Enrollment :
32 Patients enrolled
Trial Details
Trial ID
NCT03410745
Start Date
February 21 2018
End Date
September 10 2019
Last Update
September 25 2019
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Institute of Sports Medicine Copenhagen
Copenhagen, Denmark, 2400