Status:
COMPLETED
Bioelectrical Impedance Analysis as a Bedside Tool to Estimate Volume of Distribution of Hydrophilic Antimicrobials in Critically Ill Patients
Lead Sponsor:
Universitaire Ziekenhuizen KU Leuven
Collaborating Sponsors:
KU Leuven
Conditions:
Electric Impedance
Pharmacokinetics
Eligibility:
All Genders
18+ years
Brief Summary
Bioelectrical impedance analysis is studied as a bedside tool to estimate capillary leak in order to guide dosing of hydrophilic antimicrobials.
Detailed Description
Abstract Background: Recent data suggest that antimicrobial pharmacokinetics (PK) like volume of distribution (Vd) or drug clearance (CL) is extremely altered in critically ill patients with sepsis or...
Eligibility Criteria
Inclusion
- Admitted to ICU ward
- Treated with one of the four studied antimicrobials
Exclusion
- \<18 years
- Pregnant
- Do Not Resuscitate code 2 or 3
- Renal replacement therapy
- ECMO
- Pacemaker/defibrillator
- Extended burns or dermatological ilness
Key Trial Info
Start Date :
October 1 2015
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2016
Estimated Enrollment :
68 Patients enrolled
Trial Details
Trial ID
NCT03410771
Start Date
October 1 2015
End Date
June 1 2016
Last Update
January 30 2018
Active Locations (1)
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1
UZLeuven
Leuven, Vlaams-Brabant, Belgium, 3000