Status:
COMPLETED
Statins in Cerebral Blood Flow and Neuronal Activity--A Pilot Study
Lead Sponsor:
Cedars-Sinai Medical Center
Conditions:
Alzheimer's Disease
Eligibility:
All Genders
45-65 years
Brief Summary
Specific Aim: Demonstrate that statins have an effect on cerebral blood flow and neuronal activity
Detailed Description
A number of recent of recent studies suggests that statins, typically used to lower blood cholesterol have an effect on the brain. Patients treated with statins may have increased blood flow in the br...
Eligibility Criteria
Inclusion
- Otherwise healthy adults, male or female
- Age 45-65,
- Prior to treatment with any statin at a moderate or high dose -
Exclusion
- Previous cerebral vascular accident,
- Traumatic brain injury,
- Subarachnoid hemorrhage,
- Vascular dementia,
- Alzheimer's Disease A
- Any other known vascular pathologies of the brain.
- Patients taking and/or receiving other known cerebrovascular enhancing medication/herbs and/or treatment (examples: tPA, gingko, triple H therapy, stenting procedures, etc.)
- Previous neurosurgery or intracranial procedures.
- Contraindication to MRI (pacemaker, neurostimulator, other surgical implants or metals which would contraindicate MRI).
Key Trial Info
Start Date :
April 1 2007
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2010
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT03411291
Start Date
April 1 2007
End Date
September 1 2010
Last Update
February 19 2018
Active Locations (1)
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1
Cedars-Sinai Medical Center, S. Mark Taper Foundation Imaging Center
Los Angeles, California, United States, 90048