Status:
UNKNOWN
Effect of Antibiotics on Penile Microbiome and HIV Susceptibility Study in Ugandan Men
Lead Sponsor:
University of Toronto
Collaborating Sponsors:
UVRI-IAVI HIV Vaccine Program
Entebbe General Hospital
Conditions:
Foreskin HIV Susceptibility
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This pilot study will assess the impact of four antimicrobial products (3 topical, one systemic) on the foreskin microbiome and HIV susceptibility of foreskin-derived CD4+ T cells. Participants will i...
Detailed Description
RATIONALE: The foreskin is the site of most HIV acquisition in uncircumcised heterosexual men, and male circumcision (MC) reduces HIV risk by almost 60%. However, cultural and practical barriers have ...
Eligibility Criteria
Inclusion
- Enrollment criteria include:
- Aged 18 years or older
- Biological male
- Uncircumcised
- HIV seronegative
- Willing to comply with the requirements of the protocol
- No current sexually transmitted infection (N. gonorrhoeae or C. trachomatis)
- No clinically relevant genital symptoms / signs
Exclusion
Key Trial Info
Start Date :
December 7 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 7 2019
Estimated Enrollment :
125 Patients enrolled
Trial Details
Trial ID
NCT03412071
Start Date
December 7 2017
End Date
December 7 2019
Last Update
January 26 2018
Active Locations (1)
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1
UVRI-IAVI HIV Vaccine Program
Entebbe, Wakiso, Uganda