Status:
COMPLETED
A Dose Escalation Trial of Five Fraction Stereotactic Radiation Therapy for Brain Metastases
Lead Sponsor:
University of Alabama at Birmingham
Conditions:
Brain Metastases
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study looks at dose escalation for five fraction stereotactic radiotherapy for patients diagnosed with brain metastases with tumors 2.1-4.0 cm in diameter or 4.1-6.0 cm in diameter.
Detailed Description
This study looks at dose escalation treatment in patients diagnosed with brain metastases. Treatment involve five fraction stereotactic radiotherapy for patients with brain tumors 2.1-4.0 cm in diamet...
Eligibility Criteria
Inclusion
- All patients must have histologically confirmed malignancy.
- All patients must have imaging suggestive of one or more brain metastases.
- Karnofsky performance status (KPS) ≥ 60
- Age \> 18 years
- Patients must provide written informed consent to participate in the study.
- Patients must have less than or equal to 10 brain metastases as identified on brain MRI.
Exclusion
- History of surgical resection to the tumor of interest
- History of radiation to the tumor of interest
- History of previous whole brain irradiation
- Receipt of systemic therapy within one week of planned radiation treatment except for hormonal agents.
- Patient is unable to have MRI or MRI contrast.
- Inability to meet the appropriate normal tissue dose constraints secondary to tumor location should result in exclusion of the patient / tumor.
- Patients with a non-index tumor (second tumor) greater than 3 cm in diameter will be excluded.
Key Trial Info
Start Date :
July 30 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2025
Estimated Enrollment :
13 Patients enrolled
Trial Details
Trial ID
NCT03412812
Start Date
July 30 2018
End Date
October 1 2025
Last Update
November 4 2025
Active Locations (1)
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1
Hazelrig-Salter Radiation Oncology Center
Birmingham, Alabama, United States, 35233