Status:
COMPLETED
Effect of Exercise on Genes That Control Muscle Function
Lead Sponsor:
Baylor College of Medicine
Collaborating Sponsors:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
US Department of Veterans Affairs
Conditions:
Healthy
Eligibility:
All Genders
20-40 years
Phase:
NA
Brief Summary
The proposed project will examine how exercise counteracts metabolic disorders and type 2 diabetes through regulating gene expression. The project is highly relevant to public health because of the gl...
Detailed Description
Exercise is a first-line treatment for type 2 diabetes, and exerts its beneficial effects not only by burning off energy but also by causing prolonged metabolic changes through changing gene expressio...
Eligibility Criteria
Inclusion
- Age 20 - 40 years
- BMI 18.5 - 29.9
- Stable body weight (not more than 2 kg change) during the past 6 months
- Moderate sedentary (regular exercise less than 1 hour per week for the last 6 months)
- Willing to provide informed consent
Exclusion
- Failure to provide informed consent
- Any major chronic disease or any condition that would interfere with exercise, in which exercise is contraindicated, or that would interfere with interpretation of results
- Severe orthopedic and or neuromuscular disease that would contraindicate participation in exercise
- Other significant co-morbid disease that would impair ability to exercise
- Uncontrolled hypertension (BP greater than 160/90)
- History of malignancy during the past 5 years
- Diabetes mellitus as determined by self-report with verification (medical records, current treatment, confirmation from health care provider), or HbA1c of exceeding 6.5%
Key Trial Info
Start Date :
February 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 31 2022
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT03414385
Start Date
February 1 2018
End Date
May 31 2022
Last Update
March 23 2023
Active Locations (1)
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1
Baylor College of Medicine/Michael E DeBakey VA Medical Center
Houston, Texas, United States, 77030