Status:
COMPLETED
Demonstration of Carbonyl Stress on Hair Follicles
Lead Sponsor:
Pierre Fabre Dermo Cosmetique
Conditions:
Effluvium; Telogen
Eligibility:
FEMALE
18-40 years
Phase:
NA
Brief Summary
In this study, the investigator will try to highlight the presence of carbonyl compounds in the hair follicles of women with telogen effluvium (ET) linked to stress of various origins (fatigue, infect...
Detailed Description
At the cutaneous level, oxidative stress induces the formation of carbonyl compounds which, by binding to proteins, produce nonfunctional adducts inducing cutaneous aging. Is this mechanism, called "C...
Eligibility Criteria
Inclusion
- Criteria related to the Population :
- Women aged from 18 to 40 ans (included)
- Phototype I à IV included, according to Fitzpatrick Classification
- Hair length 5 cm on the sampling area (centro-parietal part)
- Last shampoo at least 2 days before the inclusion visit, without application of styling product, care or water between this last shampoo and the inclusion
- Informed consent signature
- Criteria related to the studied condition:
- ET group: hair loss related to various etiologies evaluated by a questionnaire according to the investigator's opinion and positive pull test (at least 3 hair collected per lock of 50 to 60 hair) AND
- Control group : no hair loss, evaluated by the questionnaire and negative pull test (less than 3 hair collected per lock of 50 to 60 hair)
Exclusion
- Criteria related to Population :
- Menopause
- Pregnancy, breastfeeding, childbirth for less than 6 months
- Criteria related to Pathology :
- For both groups:
- Alopecia causing hair loss on the upper part of the scalp
- Dermatological pathology or evolving cutaneous lesion in the scalp
- Control group only:
- Chronic unstabilized condition
- Acute evolving pathology
- Criteria related to theTreatments :
- For both groups:
- Use for at least 1 month of Minoxidil, Aminexil in the 3 months before inclusion or ongoing
- Systemic treatment affecting hair growth
- Any treatment or dietary supplement for antioxidant or capillary
- Control group only:
- Treatment of general thyroid disorders initiated or modified for less than 3 months prior to inclusion
- Treatment of anemia if started less than 3 months before inclusion
- General treatment initiated or modified for less than 3 months prior to inclusion in the study
Key Trial Info
Start Date :
March 26 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 25 2018
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03414476
Start Date
March 26 2018
End Date
June 25 2018
Last Update
January 21 2020
Active Locations (6)
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1
Centre hospitalier Lyon Sud
Lyon, France, 69007
2
Centre de Pharmacologie Clinique Appliquée à la Dermatologie
Nice, France, 06202
3
Centre de santé SABOURAUD
Paris, France, 75010
4
INTERTEK France
Paris, France, 75013