Status:
COMPLETED
High-intensity Interval Training in Patients With Post-acute Coronary Syndrome
Lead Sponsor:
Montreal Heart Institute
Conditions:
Acute Coronary Syndrome
Arrhythmia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
To date, no studies have evaluated the safety or efficiency (improvement of maximal oxygen uptake \[VO2peak\]) of a high-intensity interval training (HIIT) program in post-acute coronary syndrome (pos...
Eligibility Criteria
Inclusion
- Males or females aged ≥ 18 years
- Acute coronary syndrome within 6 weeks (unstable angina, or non-ST elevation myocardial infarction (NSTEMI), or ST elevation myocardial infarction (STEMI with the presence of 2/3 criteria (i.e. typical chest pain, electrocardiographic ischemic change or elevated troponin T
- Complete revascularization defined as no major epicardial coronary artery or bypass graft with a residual diameter stenosis \>50% and no residual left main stenosis ≥40%
- Left ventricular ejection fraction \>40%
- Stable doses of medication during the 4 weeks prior to enrolment (STEMI patients must be on a stable dose of beta-blocker)
- Able to perform a maximal cardiopulmonary exercise test, 7) capacity and willingness to sign informed consent.
Exclusion
- Recent coronary bypass surgery (\<6 months)
- Incomplete revascularisation, left ventricular ejection fraction \<40%
- Significant valvular disease (mitral stenosis, moderate to severe mitral insufficiency, aortic stenosis, or aortic insufficiency)
- Uncontrolled hypertension (systolic blood pressure/diastolic blood pressure \>180/110 mmHg)
- Significant resting electrocardiogram abnormalities (left bundle branch block, non-specific intraventricular conduction delay, left ventricular hypertrophy, resting ST-segment depression)
- Chronic atrial fibrillation
- Pacemaker or implantable cardioverter defibrillator
- Low functional capacity (\<5 basal Metabolic Equivalent of Task \[METs\])
- Change of cardiac medications within 4 weeks of enrolment and any contraindication to exercise testing or exercise training.
Key Trial Info
Start Date :
January 1 2011
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 30 2021
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT03414996
Start Date
January 1 2011
End Date
December 30 2021
Last Update
September 13 2022
Active Locations (1)
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1
Cardiovascular prevention and rehabilitation center
Montreal, Quebec, Canada, H1T 1N6