Status:
WITHDRAWN
Effects of Prazosin on the Attention-Enhancing Effects of Nicotine
Lead Sponsor:
University of Maryland, Baltimore
Conditions:
no Condition, Basic Science
Eligibility:
All Genders
21-55 years
Phase:
NA
Brief Summary
To test whether specific aspects of the attention-enhancing effects of nicotine may be mediated by down-stream activation of alpha1 adrenoceptors, the interaction of nicotine and the alpha1 adrenergic...
Detailed Description
Drugs that activate nicotinic acetylcholine receptors (nAChRs), such as nicotine, have cognitive enhancing, and in particular attention-enhancing effects that may be of clinical benefit to individuals...
Eligibility Criteria
Inclusion
- Aged 21 to 55 years.
- Smoked no more that 40 cigarettes, cigars or cigarillos in lifetime.
- Smoked no cigarettes, cigars or cigarillos in the last year.
- No exposure to any nicotine-containing product in the last month.
- Normal or corrected to normal vision (at least 20/80).
Exclusion
- Pregnant or breast-feeding.
- Drug or alcohol abuse or dependence currently or in the last 2 years.
- DSM Axis I mood, anxiety or psychotic disorder.
- Cardiovascular or cerebrovascular disease.
- Hypertension (resting systolic BP above 150 or diastolic above 95 mm Hg).
- Hypotension (resting systolic BP below 90 or diastolic below 60).
- Bradycardia (heart rate \<60 bpm).
- Impaired liver or kidney function.
- Severe asthma.
- Obstructive pulmonary disease.
- Type I diabetes.
- Use of any centrally active medications.
- Use of any cardiovascular drugs, including blood pressure medications and antiarrhythmics.
- Use of diuretic medication.
- History of or current neurological illnesses, such as stroke, seizure disorders, neurodegenerative diseases, or organic brain syndrome.
- Learning disability, mental retardation, or any other condition that impedes cognition.
- Planned eye surgery.
- Inability to perform the Rapid Visual Information Processing Task.
- Known hypersensitivity to prazosin, any quinazolines, or nicotine.
- Narcolepsy.
Key Trial Info
Start Date :
March 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2019
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT03416569
Start Date
March 1 2018
End Date
January 1 2019
Last Update
August 19 2019
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