Status:
RECRUITING
Central Nervous System Infections in Denmark
Lead Sponsor:
Aalborg University Hospital
Collaborating Sponsors:
Danish Study Group of Infections of the Brain
Conditions:
Central Nervous System Infections
Bacterial Meningitis
Eligibility:
All Genders
18+ years
Brief Summary
The Danish Study Group of Infections of the Brain is a collaboration between all departments of infectious diseases in Denmark. The investigators aim to monitor epidemiological trends in central nervo...
Detailed Description
The investigators include data on diagnosis at admission, symptoms and signs on admission, character and timing of diagnostic work-up and treatment and outcome assessed by the Glasgow Outcome Score (G...
Eligibility Criteria
Inclusion
- Definitions of central nervous system infections:
- For all cases with unproven aetiologies no alternative diagnosis than CNS infection is thought more likely after completed multidisciplinary diagnostic work-up.
- Viral meningitis inclusion criteria
- \- All patients have to have a clinical presentation consistent with non-bacterial meningitis (e.g. headache, neck stiffness, photo- or phonophobia, fever)
- and
- Cerebrospinal fluid leukocytes\>10 cells/ml
- Patients with viral meningitis with undetermined pathogen have to have:
- CSF leukocytes\> 10/mL and no other more probable diagnosis assessed by the local investigator.
- In case of doubt, patients are discussed with the DASGIB secretary and chair or at meetings.
- Bacterial meningitis inclusion criteria - All patients have to have a clinical presentation consistent with bacterial meningitis (e.g. headache, neck stiffness, fever, altered mental status)
- and
- Proven bacterial aetiology (CSF or blood culture/DNA based technology or antigen tests)
- Patients with bacterial meningitis in whom the bacteria cannot not be cultured or identified by DNA-based technologies have to have:
- \- CSF leukocytes\> 10/mL and no other more probable diagnosis assessed by the local investigator.
- In case of doubt, patients are discussed with the DASGIB secretary and chair or at meetings.
- Encephalitis inclusion criteria - All patients have to have a clinical presentation consistent with encephalitis (e.g. headache, fever, focal neurological deficit, altered mental status \>24 hours) as defined by the International Encephalitis Consortium (Venkatesan A et al., Clin Infect Dis 2013; doi:10.1093/cid/cit458.).
- Encephalitis exclusion criteria
- \- We exclude cases of proven or suspected autoimmune encephalitis.
- Primary brain abscess inclusion criteria
- \- All patient have a clinical presentation consistent with brain abscess (e.g. headache, focal neurological deficit, mass lesion on cranial imaging)
- and
- \- Proven microbiological aetiology by culture/DNA-based technology from pus from brain abscess or blood or CSF
- or
- \- Aspiration of pus from the brain abscess
- or
- \- Response to antimicrobial treatment
- or
- \- Tumour ruled out
- or
- \- Tumour thought less probable than abscess on MRI using diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) sequences.
- Lyme neuroborreliosis inclusion criteria
- \- A clinical presentation consistent with neuroborreliosis (e.g. radiculopathy)
- and
- \- CSF pleocytosis\>10 leukocytes/mL
- and
- \- Positive intrathecal B.burgdorferi antibody production index.
- Neurosyphilis inclusion criteria - A clinical presentation consistent with neurosyphilis (e.g. 'encephalitis-like symptoms', dementia, ocular or otogenic syphilis)
- and either
- \- Positive syphilis serology in serum combined with CSF leukocytes\>10/mL
- or
- \- CSF syphilis antibodies.
Exclusion
Key Trial Info
Start Date :
January 1 2015
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
January 1 2030
Estimated Enrollment :
1900 Patients enrolled
Trial Details
Trial ID
NCT03418441
Start Date
January 1 2015
End Date
January 1 2030
Last Update
May 16 2024
Active Locations (8)
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1
Department of Infectious Diseases, Aalborg University Hospital
Aalborg, Denmark, 9000
2
Department of Infectious Diseases, Aarhus University Hospital Skejby
Aarhus, Denmark, 8000
3
Department of Infectious Diseases, Rigshospitalet
Copenhagen, Denmark, 2100
4
Herlev-Gentofte Hospital
Copenhagen, Denmark