Status:
COMPLETED
Simvastatin Gel With Perforated Resorbable Membranes in Treatment of Intrabony Defects in Chronic Periodontitis
Lead Sponsor:
Ain Shams University
Conditions:
Chronic Periodontitis
Eligibility:
All Genders
30-50 years
Phase:
PHASE4
Brief Summary
Modified perforated membrane (MPM) is considered as a modality that could enable participation of periosteal cells and gingival stem cells which could improve the outcomes of guided tissue regeneratio...
Detailed Description
Forty patients with 40 intrabony defects having chronic periodontitis were randomly assigned into four equal groups to receive open flap procedure, 1.2% SMV gel and covering the defect with OM (Group ...
Eligibility Criteria
Inclusion
- Patients were all healthy and free from any systemic disease.
- No history of antibiotic therapy or periodontal treatment for at least six months preceding the study.
- Patients were willing and able to return for multiple follow up visits.
- Periodontal defects with
- Probing depth \> 5 mm.
- Clinical attachment loss \>4 mm.
- Standardized radiographic evidence of interproximal intrabony defect using periapical radiograph.
- Good level of oral hygiene (plaque and gingival indices score after initial phase therapy should be less than one).
Exclusion
- Pregnancy, lactation for female patients.
- Smokers, alcoholics and those receiving any medication that could affect healing of soft tissue and bone as steroids and cyclosporines.
- History of allergic reaction to the medications used.
- Vulnerable groups and handicapped.
Key Trial Info
Start Date :
January 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2017
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT03419429
Start Date
January 1 2016
End Date
June 1 2017
Last Update
February 6 2018
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