Status:
COMPLETED
Cell Signaling and Resistance to Oxidative Stress: Effects of Aging and Exercise
Lead Sponsor:
Northern Arizona University
Conditions:
Aging
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Advanced age is the main risk factor for chronic diseases such as cardiovascular disease, type 2 diabetes, Alzheimer's disease and cancer. One reason may be due to decreased resistance to oxidative st...
Detailed Description
Advanced age substantially increases the risk for a host of diseases including cardiovascular disease, type 2 diabetes, Alzheimer's disease, and cancer. A major factor that appears to underlie this in...
Eligibility Criteria
Inclusion
- Men and women, 18-28 years or 60 years and older
- Competent to independently give informed consent
- Successful completion of screening
- No regular exercise for the past 6-months (by self-report)
- A score below 3.0 on the Historical Lifetime Physical Activity Questionnaire
Exclusion
- Estrogen supplementation within the previous 6 months
- Use of anti-oxidant supplements, in excess of standard multi-vitamins (1 tablet/day)
- Current smoker
- Body Mass Index (BMI) ≤33 kg/m2 (Class I Obesity)
- Any chronic illness that could affect outcome measures, including diabetes, liver or renal disease, or cancer (other than skin cancer)
- History of a myocardial infarction within the last 6 months, clinically significant aortic stenosis, use of cardiac defibrillator, or uncontrolled angina
- Clinically significant arrhythmia on a resting EKG or significant EKG changes during the baseline maximal oxygen consumption (VO2 max) test
- Any other condition that would contraindicate maximal exercise testing, including elevated blood pressure at rest (systolic BP \>150 or diastolic BP \>90 mm Hg on at least 2 measurements, at least 10 minutes apart) or musculoskeletal problems
Key Trial Info
Start Date :
June 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 30 2020
Estimated Enrollment :
46 Patients enrolled
Trial Details
Trial ID
NCT03419988
Start Date
June 1 2017
End Date
June 30 2020
Last Update
August 26 2020
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Northern Arizona University
Flagstaff, Arizona, United States, 86011