Status:
COMPLETED
Venous Thromboembolism in Myotonic Dystrophy Type 1
Lead Sponsor:
Assistance Publique - Hôpitaux de Paris
Collaborating Sponsors:
AFM-Téléthon (Funding)
Recherche Clinique Paris Descartes Necker Cochin Sainte Anne
Conditions:
Myotonic Dystrophy 1
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Investigators identified a high risk of deep vein thrombosis and pulmonary embolism in patients presenting myotonic dystrophy type 1 treated in our hospital, 10 times higher than general population ma...
Detailed Description
Investigators have identified in the cohort of 1084 patients presenting myotonic dystrophy type 1 (DM1) a 10% prevalence of venous thromboembolism (VTE) and a 7‰ annual incidence, which is 10-fold hig...
Eligibility Criteria
Inclusion
- Population N°1
- Age over 18 years
- Patient living in France and with medical insurance
- Patient having given his informed and written consent
- DM1 groups: genetically proven DM1
- VTE groups: at least 1 history of VTE (PE and/or DVT)
- Healthy volunteers: patient without any medical history (no DM1, no VTE, no thrombophilia), and without taking any anti-thrombotic medication
- Population N°2
- Liver tissue of patients with genetically proven DM1 (tissue bank)
- Liver tissue of patients without DM1 or any history of VTE (tissue bank)
Exclusion
- Patient opposed to data collection and analysis
- 1\. Population N°1
- Genetically proven thrombophilia
- Anti-thrombotic medication
- Hemoglobin levels \< 7 g/dL
- Hemoglobin levels \< 9 g/dL in case of cardiac of respiratory condition
- 2\. Population N°2
- Liver tissue quality insufficient for RNA extraction and analysis
Key Trial Info
Start Date :
June 11 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 15 2023
Estimated Enrollment :
130 Patients enrolled
Trial Details
Trial ID
NCT03424460
Start Date
June 11 2018
End Date
March 15 2023
Last Update
September 12 2025
Active Locations (1)
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1
Service de Cardiologie - Hôpital Cochin
Paris, Île-de-France Region, France, 75014