Status:
COMPLETED
Sequential Treatment With BELKYRA® Then Juvéderm® VOLUMA™ With Lidocaine for Overall Improvement in Jawline Contour
Lead Sponsor:
Allergan
Conditions:
Contour
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
This study has been designed to evaluate the safety and effectiveness of sequential treatment with BELKYRA® (for the treatment of convexity and fullness associated with submental fat) and VOLUMA™ (to ...
Detailed Description
Participants may be treated with up to 6 treatments with Belkyra, followed by treatment with Voluma. Participants will have opportunity to participation in a skin biopsy sub-study.
Eligibility Criteria
Inclusion
- Grade 2 or above on Allergan Loss of Jawline Definition Scale (ALJDS)
- Grade 2 or 3 on reported Clinician-Rated Submental Fat Rating Scale (CR-SMFRS)
- Stable body weight for at least 26 weeks
- Accept the obligation to forego any treatment or behavior (e.g., unshaven facial hair; significant changes to dietary or exercise habits) during the participants participation in the study that may affect the assessments of the submental area
Exclusion
- Grade 4 on Submental Skin Laxity Grade (SMSLG)
- Grade 4 on Allergan Jowl Fat Rating Scale (AJFRS)
- Body mass index (BMI) \>35 kg/m\^2
- History of, or current symptoms of dysphagia
- History of temporary, semi-permanent or permanent facial or neck dermal filler injections below the medial canthi at any time prior to treatment, or within 52 weeks before Screening for treatment above the medial canthi
- History of facial and/or neck plastic surgery, tissue grafting or permanent facial implants anywhere in the face or neck
- History of any intervention (e.g., liposuction, surgery, or lipolytic agents) to treat submental fat (SMF)
- Evidence of any cause of enlargement in the submental area other than localized SMF
- History of mesotherapy or ablative procedures to the face and/or neck 52 weeks before Screening
- History of skin resurfacing in the neck or submental area within 26 weeks before Screening
- Treatment with botulinum toxin injections in the neck or submental area within 26 weeks before Screening
- Participants on prescription topical retinoid therapy and/or topical hormone cream applied to the face, who have not been on a consistent dose regimen for at least 26 weeks before Screening and who are unable to maintain regimen for the study
- Systemic retinoid therapy within 52 weeks before Screening
- Current use of oral corticosteroids
- Is on a regimen of anticoagulation therapy (eg, warfarin, clopidogrel)
- Has current injection site inflammatory or infectious processes, abscess, an unhealed wound, or a known cancerous or precancerous lesion in chin, masseter, or submental region
- Planned oral surgery or other dental procedures (e.g., tooth extraction, orthodontia, or implantation) within 2 weeks prior to and after VOLUMA™ treatment
Key Trial Info
Start Date :
February 2 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 5 2019
Estimated Enrollment :
58 Patients enrolled
Trial Details
Trial ID
NCT03425253
Start Date
February 2 2018
End Date
December 5 2019
Last Update
December 31 2020
Active Locations (3)
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1
Darlinghurst Dermatology
Darlinghurst, New South Wales, Australia, 2010
2
Living Art
East Melbourne, Victoria, Australia, 3002
3
Dermatology Institute of Victoria
South Yarra, Victoria, Australia, 3141