Status:
UNKNOWN
Association of Endodontic Infection With Cardiovascular Disease.
Lead Sponsor:
Postgraduate Institute of Dental Sciences Rohtak
Conditions:
Apical Periodontitis
Eligibility:
MALE
20-40 years
Brief Summary
Chronic inflammation plays a crucial role in the genesis of atherosclerosis and at the same time promotes acute cardiovascular events. Periodontal and pulpal inflammation are two major low grade chron...
Detailed Description
Cardiovascular Disease (CVD) is the primary non-communicable cause of global mortality killing more than 7 million people per year. Chronic inflammation plays a crucial role in the genesis of atherosc...
Eligibility Criteria
Inclusion
- 20-40 years of Male.
- Presence of apical periodontitis as assessed both clinically and radiographically (teeth with apical symptoms but without radiographic appearance of AP were not include).
- Presence of at least 25 teeth.
- Echocardiographic Left Ventricle Ejection Fraction (LVEF) value \>55%.
- Hepatic and renal function within normal limits (bilirubin\<1.5mg/dl; creatine\<2.0mg/dl).
Exclusion
- Presence of localized or diffuse periodontal disease.
- Presence of non-endodontic lesion in Maxilla/ mandible.
- Presence of cardiovascular risk factors(arterial hypertension, dyslipidemia, DM, obesity, smoking)
- LV hypertrophy at echocardiography previous or current CVD.
- Presence of chronic inflammatory conditions in other regions involving systemic health.
- For women, use of anticonceptive hormones.
- Systemic antibiotic treatment within the previous 3 months or any other regular medication.
Key Trial Info
Start Date :
November 1 2016
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 30 2018
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT03425383
Start Date
November 1 2016
End Date
March 30 2018
Last Update
February 7 2018
Active Locations (1)
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1
Post Graduate Institute of Dental Sciences
Rohtak, Haryana, India, 124001