Status:
TERMINATED
A Phase I Dose-escalation Study of Subcutaneous ALM201 in Patients With Advanced Ovarian Cancer and Other Solid Tumours
Lead Sponsor:
Almac Discovery
Conditions:
Solid Tumors
Ovarian Cancer
Eligibility:
All Genders
16+ years
Phase:
PHASE1
Brief Summary
ALM201/0001 is a Phase I, open-label, dose-escalation study of the safety, tolerability and pharmacokinetics (PK) of ALM201. Part 1 will be a dose-escalation study. Patients with advanced solid tumou...
Detailed Description
ALM201 is a peptide with anti-angiogenic activity in a range of in-vitro and ex-vivo models. ALM201/0001 is a Phase I, multicentre, open-label, dose-escalation study of the safety, tolerability and ph...
Eligibility Criteria
Inclusion
- Part 1 Specific Inclusion Criterion
- \*Patients with histologically and/or cytologically confirmed advanced solid tumour for whom no standard effective therapy is available or felt likely to be of limited efficacy and in whom a rationale for use of an anti-angiogenic treatment approach exists. Note: Previous use of anti-angiogenic therapy is allowed if tolerated
- Part 2 Specific Inclusion Criterion
- \*Patients with advanced ovarian cancer, who are intolerant of or whose tumour is resistant to platinums and who have failed to respond to, or have relapsed following, standard therapy and whose tumour has a proangiogenic profile as assessed by the angiogenesis gene signature test. Note: Previous use of anti-angiogenic therapy is allowed if tolerated.
- General Inclusion Criteria for all Patients
- Measurable or evaluable disease.
- Recovery from previous treatment to baseline or CTCAE ≤ Grade 1, as determined by CTCAE v4.03 criteria (Appendix B), of reversible toxicities related to prior treatment, with the exception of alopecia, lymphopenia, other non-clinically significant adverse events; recovery from previous radiotherapy other than residual cutaneous effects or stable \< Grade 2 gastrointestinal toxicity; complete recovery from surgery other than stable \< Grade 2 toxicity.
- ECOG Performance Status (PS) of 0 or 1.
- Acceptable haematological, renal and hepatic
- Women must have either a negative pregnancy test prior to first study drug administration or be post menopausal. Male and female patients of childbearing potential must use appropriate methods birth control.
- Patients must give written informed consent and understand the requirements of the study
Exclusion
- For all Patients
- History of inability to tolerate anti-angiogenic therapies e.g. increased blood pressure (BP), proteinuria, prior thromboembolic events.
- Previous history of bowel obstruction, clinical evidence of gastro-intestinal obstruction, large burden of peritoneal disease or evidence of bowel involvement on computed tomography.
- Patents has received:
- any chemotherapy regimens (including investigational agents) with delayed toxicity within 4 weeks (6 weeks for prior nitrosourea or mitomycin C) of Cycle 1, Day 1, or received chemotherapy regimens given continuously or on a weekly basis which have limited potential for delayed toxicity within 2 weeks of Cycle 1, Day 1.
- radiotherapy, immunotherapy or biological agents (includes investigational agents) within 4 weeks of Cycle 1, Day 1. Localised palliative radiotherapy is permitted for symptom control.
- Documented, symptomatic or uncontrolled intracranial metastases or primary intracerebral tumours.
- Cancer with leptomeningeal involvement.
- On therapeutic anti-coagulation (aspirin dosing ≤100 mg per oral (PO) daily allowed).
- Previous malignancy, except for non-basal-cell carcinoma of skin or carcinoma-in-situ of the uterine cervix, unless the tumour was treated with curative intent more than 2 years prior to study entry.
- Active cardiac condition or history of significant cardiac condition. Known human immunodeficiency virus positivity.
- Active hepatitis B or C or other active liver disease (other than malignancy).
- Any active, clinically significant, viral, bacterial, or systemic fungal infection within 4 weeks prior to Cycle 1, Day 1.
- Any evidence of severe or uncontrolled systemic conditions or any other issues which make it undesirable for the patient to participate in the study or which could jeopardize compliance with the protocol.
Key Trial Info
Start Date :
April 27 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 13 2017
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT03427073
Start Date
April 27 2015
End Date
March 13 2017
Last Update
September 11 2019
Active Locations (3)
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1
Centre for Cancer Research and Cell Biology, Queen's University Belfast
Belfast, County Antrim, United Kingdom, BT9 7AB
2
Dept Medical Oncology, The Christie NHS Foundation Trust
Manchester, Lancashire, United Kingdom, M20 4BX
3
Freeman Hospital, Northern Centre for Cancer Care, Sir Bobby Robson Cancer Trial research Centre
Newcastle, Northumberland, United Kingdom, NE7 7DN