Status:
COMPLETED
Novel Nutrition Solutions for Sarcopenia
Lead Sponsor:
University College Dublin
Conditions:
Sarcopenia
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
This study will examine the effect of leucine-enriched protein supplementation, alone and in combination with long chain n-3 polyunsaturated fatty acids (LC n-3 PUFA), on muscle mass and function in o...
Detailed Description
The progressive loss of skeletal muscle mass and function with advancing age, termed sarcopenia, contributes substantially to disability, physical dependence, and mortality among older adults. Aging i...
Eligibility Criteria
Inclusion
- Age: ≥65 y
- Sex: males and females
- Low muscle mass (assessed via bioelectrical impedance analysis using cut-offs from Janssen, 2004) and/or low handgrip strength (\< 30 kg men, \<20kg women)
Exclusion
- BMI \>35 kg/m2
- Cancer - malignancy in the past 5 years
- Multiple Sclerosis, Parkinsons Disease
- Chronic kidney disease
- Liver failure
- Diabetes
- Conditions that will affect ability to consume, digest and/or absorb the study drink (i.e. cows milk protein allergy, inflammatory bowel disease)
- Smokers
- Cognitive function \< 21 on Mini-Mental State Examination
- Excess alcohol intake
- Regular resistance training
- Total walking incapacity
- Musculoskeletal or neuromuscular impairments that could interfere with strength testing
- Medications interfering with muscle metabolism
- Adherence to a high energy or high protein diet three months before starting and during the study. Use of protein containing or amino acid containing nutritional supplements three months before starting and during the study.
- High consumers of oily fish.
- Weight change \> 3 kg past 3 months
Key Trial Info
Start Date :
June 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 21 2018
Estimated Enrollment :
108 Patients enrolled
Trial Details
Trial ID
NCT03429491
Start Date
June 1 2017
End Date
December 21 2018
Last Update
April 18 2019
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University College Dublin
Dublin, Ireland