Status:
COMPLETED
Ketamine for Acute Painful Crisis in Sickle Cell Disease Patients
Lead Sponsor:
Imam Abdulrahman Bin Faisal University
Conditions:
Sickle Cell Crisis
Eligibility:
All Genders
18-60 years
Phase:
NA
Brief Summary
Investigators hypothesize that administration of ketamine for pain relief in sickle cell patients with vaso-occlusive crisis early on will lead to a more rapid improvement in pain score and less narco...
Detailed Description
Sickle cell disease is an inherited hematological disorder where the shape of red blood cells (RBC) is altered into a sickle-like cells resulting in red blood cell destruction and therefore anemia and...
Eligibility Criteria
Inclusion
- Known diagnosis of SCD based on sickle cell tests and hemoglobin electrophoresis.
- Age 18 to 60 years
- Acute onset of painful crises, defined as having an onset within 7 days
Exclusion
- Pregnancy
- Breast-feeding
- Altered mental status
- Body mass index greater than 40 kg/m2
- Patients with significant neurological disease
- Seizures
- Acute head injury
- Acute eye injury
- Patients with high intra-cranial tension
- Patients with known psychiatric disorders
- Patients with significant cardiac diseases
- Arrhythmias
- Patients with significant pulmonary diseases rather than acute chest syndrome
- Patients with significant renal disease (BUN/creatinine ratio \< 25)
- Patients with significant hepatic disease (Child Pugh class B or C)
- Patients with significant endocrine disease
- Known allergy to phencyclidine derivatives
- Known allergy to ketamine
- Known allergy to morphine
- Sepsis
- Septic shock
- Patients required circulatory support
- Patients required ventilatory supports
- Alcohol abuse
- Drug abuse
- Patients with chronic pain status unrelated to SCD
- Patients receiving anti-convulsant medications
- Patients receiving anti-psychiatric medications.
- Patients with communication barriers.
Key Trial Info
Start Date :
January 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2019
Estimated Enrollment :
278 Patients enrolled
Trial Details
Trial ID
NCT03431285
Start Date
January 1 2018
End Date
February 1 2019
Last Update
May 28 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Imam Abdulrahman Bin Faisal University
Dammam, Eastern Province, Saudi Arabia, 31952