Status:
COMPLETED
Behavioral Activation-Rehabilitation to Improve Depressive Symptoms & Physical Function After Acute Respiratory Failure
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Respiratory Insufficiency
Depression
Eligibility:
All Genders
18-100 years
Phase:
NA
Brief Summary
More and more people are surviving after receiving life support for respiratory failure in the intensive care unit, but these patients often experience problems with depression and physical functionin...
Detailed Description
A growing number of Acute Respiratory Failure (ARF) survivors are burdened by depressive symptoms and physical impairments that last for years after intensive care unit discharge. Notably, depressive ...
Eligibility Criteria
Inclusion
- ≥18 years old
- Living at home before the current admission (not in a facility)
- Acute respiratory failure managed in the ICU \> 24hrs (≥1 of the following):
- Mechanical ventilation via an endotracheal tube or tracheostomy \> 12hrs (and not ventilator-dependent before admission) OR
- Non-invasive ventilation (CPAP, BiPAP) \> 4 hours in a 24 hour period provided for acute respiratory failure (not for Obstructive Sleep Apnoea (OSA) or other stable use) OR
- High flow nasal cannula with Fraction of Inspired Oxygen (FiO2) ≥ 0.5 for ≥4 hours in a 24hr period
- At least mild depressive symptoms (score ≥2 on PHQ-2 scale)
Exclusion
- Pre-existing cognitive impairment (based on review of medical records, or proxy- administered Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) score \>3.3)
- Declines informed consent or not capable of providing informed consent
- Non-English speaking
- Homelessness or living \>50 miles away from study site
- Bedbound prior to the current admission
- Expected survival \< 6 months according to ICU attending
- ICU Length Of Stay (LOS) \> 30 days
- Not discharged home from the hospital
- Complex medical care expected soon after discharge (e.g. multiple planned surgeries, transplantation evaluation, extensive travel needs for hemodialysis, chemotherapy or radiation therapy, etc)
- Active substance abuse or psychosis
- Lack of access to telephone or inability to use telephone independently
- Pregnancy
- Suicidality
- Incarcerated
Key Trial Info
Start Date :
March 2 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 18 2024
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT03431493
Start Date
March 2 2018
End Date
July 18 2024
Last Update
September 22 2025
Active Locations (1)
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1
Johns Hopkins University
Baltimore, Maryland, United States, 21205