Status:
UNKNOWN
Switching From SSRI to Desvenlafaxine on Cognitive Functioning
Lead Sponsor:
Corporacion Parc Tauli
Collaborating Sponsors:
Pfizer
Conditions:
Major Depressive Disorder
Eligibility:
All Genders
18-60 years
Brief Summary
Given the importance of cognitive function on depressed patients' treatment outcome and return to premorbid functioning, the effect of antidepressant drugs on cognition has become of primary concern. ...
Detailed Description
BACKGROUND Depression is a significant contributor to the global burden of disease and affects people in all communities across the world. Today, depression is estimated to affect 350 million people....
Eligibility Criteria
Inclusion
- MDD Patients in whom switching to desvenlafaxine is considered by treating psychiatrist as the next treatment option.
- MDD diagnostic confirmation with the mini-international neuropsychiatric interview (MINI) (Sheehan et al., 1998),
- Age range between 18 and 60
- Non-response or incomplete response to a treatment with an SSRI in the current episode.
- Score of 18 points or higher in the Hamilton depression rating scale (HAM-D-17) (Hamilton, 1967).
Exclusion
- Subjects will be excluded if they met criteria or had past history for the following disorders: posttraumatic stress disorder, obsessive-compulsive disorder, schizophrenia, psychotic, delusional, bipolar or substance abuse disorders. MINI will be used to exclude these potentially comorbid disorders.
- Subjects with any present or past disease involving the nervous central system
- A clinically significant unstable illness or clinically significant abnormal vital signs as determined by the investigator
- Women entering the study could not be pregnant, and had to be oral contraceptive-free.
Key Trial Info
Start Date :
April 3 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 3 2019
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT03432221
Start Date
April 3 2018
End Date
June 3 2019
Last Update
April 18 2019
Active Locations (1)
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1
Corporació Sanitària Parc Taulí
Sabadell, Spain, 08208