Status:
COMPLETED
Androgen Receptor mRNA Expression is Positively Associated With Live Birth in Women Undergoing IVF Independently of the Type of Ovarian Response
Lead Sponsor:
Aristotle University Of Thessaloniki
Conditions:
Androgen Receptor Gene Overexpression
Normal Responders
Eligibility:
FEMALE
20-42 years
Brief Summary
AR is a steroid hormone receptor that regulates various genes' expression and affects cellular proliferation and differentiation. Androgens interact with AR, exert their paracrine action on granulosa ...
Eligibility Criteria
Inclusion
- Women with poor ovarian response according to bologna criteria
- Advanced maternal age (≥40 years) or any other risk factor for poor ovarian response
- A previous poor ovarian response (≤3 oocytes with a conventional stimulation protocol)
- Abnormal ovarian reserve test, (AFC ˂5-7 follicles or AMH ˂0.5-1.1 ng/ml).
- Women with normal ovarian response with normal menstrual cycles, normal astral follicle count and normal hormonal assay.
Exclusion
- Not more than 43 years old.
- No history of malignancies, endometriosis or polycystic ovary syndrome.
- Underlying genetic cause of infertility
- History of severe cardiac, hepatic or renal disease.
- History of systemic disease or treatment during the last three (3) months
- Participation in another interventional study and a likelihood of being unavailable for follow-up.
Key Trial Info
Start Date :
September 14 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 10 2018
Estimated Enrollment :
67 Patients enrolled
Trial Details
Trial ID
NCT03433768
Start Date
September 14 2014
End Date
January 10 2018
Last Update
February 15 2018
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