Status:
SUSPENDED
Clinical Characteristics of Parkinson's Disease Subjects With Severe Hypertension During Motor OFFs.
Lead Sponsor:
Oregon Health and Science University
Conditions:
Parkinson Disease
Hypertension
Eligibility:
All Genders
18-99 years
Brief Summary
Current management of hypertension in PD motor fluctuators is flawed. The current practice often is to treat transient hypertensive spikes reported by patients or measured in clinics with anti-hyperte...
Detailed Description
This is an observational study. This study will only recruit Parkinson's subjects with rises in systolic blood pressure exceeding 50% of baseline during motor off periods to select for subjects with s...
Eligibility Criteria
Inclusion
- Idiopathic Parkinson's disease fulfilling UK Brain Bank clinical criteria.
- Treatment with chronic levodopa (levodopa treatment for ≥ 3 years).
- Rise in "OFF" systolic blood pressure exceeding 50% of baseline "ON" systolic blood pressure as shown by at home monitoring.
- History of "wearing off" prior to 4 hours after the previous levodopa dose per patient report or chart documentation.
Exclusion
- Daily beta-blocker therapy.
- Diabetes mellitus, autonomic neuropathy, or other condition known to alter autonomic functions.
- Significant cognitive impairment as measured by the Montreal Cognitive Assessment score of \< 16
Key Trial Info
Start Date :
February 6 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2022
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT03433950
Start Date
February 6 2018
End Date
December 31 2022
Last Update
November 16 2021
Active Locations (1)
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1
VA Portland Health Care System
Portland, Oregon, United States, 97239