Status:
COMPLETED
Network-Level Effects of Nitrous Oxide in the Human Brain
Lead Sponsor:
University of Michigan
Conditions:
Healthy
Eligibility:
All Genders
21-40 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to understand how a commonly used drug, nitrous oxide, acts on the brain to reduce pain. Nitrous oxide is commonly used in anesthesiology but there is limited knowledge on...
Detailed Description
The objective of this study is to identify the network transformations that account for the analgesic effects of nitrous oxide. Our hypothesis is that analgesic doses of nitrous oxide increase network...
Eligibility Criteria
Inclusion
- Body mass index \<30
- Must be right-handed
- Must be capable of giving written informed consent
Exclusion
- History of obstructive sleep apnea;
- History of a difficult airway with a previous anesthetic
- Gastroesophageal reflux;
- Hypertension or other cardiovascular abnormalities;
- Pulmonary hypertension;
- History of recreational drug use;
- History of chronic alcohol abuse
- Having any chronic medical illness involving pain;
- History of major depression;
- History of psychosis or bipolar disorder;
- History of methylenetetrahydrofolate reductase deficiency;
- History of a known hypersensitivity to ketamine, midazolam, Zofran, labetalol or glycopyrrolate
- History of seizures or other neurologic disorders;
- Pregnant or nursing mothers;
- Tattoos on the head or neck region - all other tattoos are subject to determination by investigators;
- Contraindications to neuroimaging methods;
- Any impairment, activity or situation that in the judgment of the Study Coordinator or Principal Investigators would prevent satisfactory completion of the study protocol.
Key Trial Info
Start Date :
July 21 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 11 2019
Estimated Enrollment :
21 Patients enrolled
Trial Details
Trial ID
NCT03435055
Start Date
July 21 2017
End Date
October 11 2019
Last Update
November 30 2021
Active Locations (1)
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1
Michigan Medicine - University of Michigan
Ann Arbor, Michigan, United States, 48109