Status:
UNKNOWN
Steroid Therapy in Acute Bronchiolitis A New Old Line of Therapy.
Lead Sponsor:
Assiut University
Conditions:
Bronchiolitis; Respiratory Syncytial Virus
Eligibility:
All Genders
3-2 years
Phase:
PHASE1
Brief Summary
The aim of the present study is to evaluate the efficacy of steroid therapy and hospital stay in patients with acute bronchiolitis at assiut university children hospital.
Detailed Description
Bronchiolitis is an acute lower respiratory tract infection in early childhood.A subcommittee of the American Academy of Pediatrics (AAP) together with the European Respiratory Society (ERS) underline...
Eligibility Criteria
Inclusion
- Infants and young children aged from 3 months to 2 years with acute bronchiolitis.
- Infants aged \<12 months with respiratory rate over 60 breaths/min, childrens aged \>12months with respiratory rate over 50 breaths/min.
- Patients with an O2- saturation, breathing room air, under 95%.
- Patients with apathy and/or refusal to eat.
- Patients with normal white blood cell count for age.
- Full term babies without chronic disease.
Exclusion
- Infants aged \< 3 months, children aged \>2 years
- known or suspected asthma (by observing the good response to first dose of salbutamol nebulization especially among those with personal history of atopy).
- Proven or suspected acute bacterial infection.
- Presence of symptoms more than 7 days.
- Previous treatment with corticosteroid by any route within 2 weeks.
- Having a contra- indication to corticosteroid.
- Severe cases requiring initial admission to intensive care unit with endotracheal intubation (in order to reduce confounding factors such as nosocomial infection or complication due to mechanical ventilation).
- A previous history of intubation.
- Premature babies (due to possible respiratory problems associated with prematurity).
- Children with chronic cardiopulmonary diseases (Bronchopulmonary- dysplasia , Congenital Heart Disease and Cystic fibrosis)
- Children with immunodeficiencies .
- Children with neuromuscular disease.
Key Trial Info
Start Date :
February 1 2019
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 1 2019
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT03436225
Start Date
February 1 2019
End Date
March 1 2019
Last Update
January 9 2019
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